論文 - 詳細
| RRC ID | 54867 |
|---|---|
| 著者 | Yu Y, Newman H, Shen L, Sharma D, Hu G, Mirando AJ, Zhang H, Knudsen E, Zhang GF, Hilton MJ, Karner CM. |
| タイトル | Glutamine Metabolism Regulates Proliferation and Lineage Allocation in Skeletal Stem Cells. |
| ジャーナル | Cell Metab |
| Abstract |
Skeletal stem cells (SSCs) are postulated to provide a continuous supply of osteoblasts throughout life. However, under certain conditions, the SSC population can become incorrectly specified or is not maintained, resulting in reduced osteoblast formation, decreased bone mass, and in severe cases, osteoporosis. Glutamine metabolism has emerged as a critical regulator of many cellular processes in diverse pathologies. The enzyme glutaminase (GLS) deaminates glutamine to form glutamate-the rate-limiting first step in glutamine metabolism. Using genetic and metabolic approaches, we demonstrate GLS and glutamine metabolism are required in SSCs to regulate osteoblast and adipocyte specification and bone formation. Mechanistically, transaminase-dependent α-ketoglutarate production is critical for the proliferation, specification, and differentiation of SSCs. Collectively, these data suggest stimulating GLS activity may provide a therapeutic approach to expand SSCs in aged individuals and enhance osteoblast differentiation and activity to increase bone mass. |
| 巻・号 | 29(4) |
| ページ | 966-978.e4 |
| 公開日 | 2019-4-2 |
| DOI | 10.1016/j.cmet.2019.01.016 |
| PII | S1550-4131(19)30016-6 |
| PMID | 30773468 |
| PMC | PMC7062112 |
| MeSH | Animals Cell Lineage* Cell Proliferation Cells, Cultured Female Glutamine / analysis Glutamine / metabolism* Male Mass Spectrometry Mice Mice, Inbred Strains Muscle, Skeletal / cytology* Muscle, Skeletal / metabolism* Myoblasts, Skeletal / cytology* Myoblasts, Skeletal / metabolism* |
| IF | 22.415 |
| 引用数 | 17 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 21 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | ST2(RCB0224) |