論文 - 詳細
| RRC ID | 5576 |
|---|---|
| 著者 | Imai T, Yamazaki T, Kobayakawa R, Kobayakawa K, Abe T, Suzuki M, Sakano H. |
| タイトル | Pre-target axon sorting establishes the neural map topography. |
| ジャーナル | Science |
| Abstract |
Sensory information detected by the peripheral nervous system is represented as a topographic map in the brain. It has long been thought that the topography of the map is determined by graded positional cues that are expressed by the target. Here, we analyzed the pre-target axon sorting for olfactory map formation in mice. In olfactory sensory neurons, an axon guidance receptor, Neuropilin-1, and its repulsive ligand, Semaphorin-3A, are expressed in a complementary manner. We found that expression levels of Neuropilin-1 determined both pre-target sorting and projection sites of axons. Olfactory sensory neuron-specific knockout of Semaphorin-3A perturbed axon sorting and altered the olfactory map topography. Thus, pre-target axon sorting plays an important role in establishing the topographic order based on the relative levels of guidance molecules expressed by axons. |
| 巻・号 | 325(5940) |
| ページ | 585-90 |
| 公開日 | 2009-7-31 |
| DOI | 10.1126/science.1173596 |
| PII | 1173596 |
| PMID | 19589963 |
| MeSH | Animals Axons / physiology* Brain Mapping Cell Communication Cues Cyclic AMP / metabolism Ligands Mice Mice, Knockout Mice, Transgenic Neuroglia / physiology Neuropilin-1 / metabolism* Olfactory Bulb / cytology Olfactory Bulb / physiology* Olfactory Mucosa / cytology Olfactory Mucosa / physiology Olfactory Pathways / cytology Olfactory Pathways / physiology* Olfactory Receptor Neurons / cytology Olfactory Receptor Neurons / physiology* Receptors, Odorant / metabolism Semaphorin-3A / metabolism Signal Transduction |
| IF | 41.846 |
| 引用数 | 142 |
| WOS 分野 | NEUROSCIENCES |
| リソース情報 | |
| 実験動物マウス | RBRC00387 RBRC01104 RBRC01106 |