RRC ID 55786
Author Mori J, Tang H, Kawabata A, Koike M, Mori Y.
Title Human Herpesvirus 6A U14 Is Important for Virus Maturation.
Journal J Virol
Abstract Human herpesvirus 6A (HHV-6A) U14 is a virion protein with little known function in virus propagation. Here, we elucidated its function by constructing and analyzing U14-mutated viruses. We found that U14 is essential for HHV-6A propagation. We then constructed a mutant virus harboring dysfunctional U14. This virus showed severely reduced growth and retarded maturation. Taken together, these data indicate that U14 plays an important role during HHV-6A maturation.
Volume 90(3)
Pages 1677-81
Published 2015-11-11
DOI 10.1128/JVI.02492-15
PII JVI.02492-15
PMID 26559847
PMC PMC4719638
MeSH Cells, Cultured Herpesvirus 6, Human / genetics Herpesvirus 6, Human / physiology* Humans Leukocytes, Mononuclear / virology Mutant Proteins / genetics Mutant Proteins / metabolism Viral Structural Proteins / genetics Viral Structural Proteins / metabolism* Virus Replication*
IF 4.324
Times Cited 4
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