| RRC ID |
55786
|
| 著者 |
Mori J, Tang H, Kawabata A, Koike M, Mori Y.
|
| タイトル |
Human Herpesvirus 6A U14 Is Important for Virus Maturation.
|
| ジャーナル |
J Virol
|
| Abstract |
Human herpesvirus 6A (HHV-6A) U14 is a virion protein with little known function in virus propagation. Here, we elucidated its function by constructing and analyzing U14-mutated viruses. We found that U14 is essential for HHV-6A propagation. We then constructed a mutant virus harboring dysfunctional U14. This virus showed severely reduced growth and retarded maturation. Taken together, these data indicate that U14 plays an important role during HHV-6A maturation.
|
| 巻・号 |
90(3)
|
| ページ |
1677-81
|
| 公開日 |
2015-11-11
|
| DOI |
10.1128/JVI.02492-15
|
| PII |
JVI.02492-15
|
| PMID |
26559847
|
| PMC |
PMC4719638
|
| MeSH |
Cells, Cultured
Herpesvirus 6, Human / genetics
Herpesvirus 6, Human / physiology*
Humans
Leukocytes, Mononuclear / virology
Mutant Proteins / genetics
Mutant Proteins / metabolism
Viral Structural Proteins / genetics
Viral Structural Proteins / metabolism*
Virus Replication*
|
| IF |
4.324
|
| 引用数 |
4
|
| リソース情報 |
| 研究用ヒト臍帯血幹細胞 |
|
