論文 - 詳細
| RRC ID | 55862 |
|---|---|
| 著者 | Bianco JN, Schumacher B. |
| タイトル | MPK-1/ERK pathway regulates DNA damage response during development through DAF-16/FOXO. |
| ジャーナル | Nucleic Acids Res |
| Abstract |
Ultraviolet (UV) induces distorting lesions to the DNA that can lead to stalling of the RNA polymerase II (RNAP II) and that are removed by transcription-coupled nucleotide excision repair (TC-NER). In humans, mutations in the TC-NER genes CSA and CSB lead to severe postnatal developmental defects in Cockayne syndrome patients. In Caenorhabditis elegans, mutations in the TC-NER genes csa-1 and csb-1, lead to developmental growth arrest upon UV treatment. We conducted a genetic suppressor screen in the nematode to identify mutations that could suppress the developmental defects in csb-1 mutants. We found that mutations in the ERK1/2 MAP kinase mpk-1 alleviate the developmental retardation in TC-NER mutants, while constitutive activation of the RAS-MAPK pathway exacerbates the DNA damage-induced growth arrest. We show that MPK-1 act via insulin/insulin-like signaling pathway and regulates the FOXO transcription factor DAF-16 to mediate the developmental DNA damage response. |
| 巻・号 | 46(12) |
| ページ | 6129-6139 |
| 公開日 | 2018-7-6 |
| DOI | 10.1093/nar/gky404 |
| PII | 5000020 |
| PMID | 29788264 |
| PMC | PMC6159517 |
| MeSH | Animals Caenorhabditis elegans / enzymology Caenorhabditis elegans / genetics Caenorhabditis elegans / growth & development Caenorhabditis elegans Proteins / genetics* Caenorhabditis elegans Proteins / metabolism* DNA Repair* Forkhead Transcription Factors / metabolism* Larva / enzymology Larva / genetics Larva / metabolism MAP Kinase Signaling System* Mitogen-Activated Protein Kinase 1 / genetics* Mitogen-Activated Protein Kinase 1 / metabolism Mutation Suppression, Genetic |
| IF | 11.147 |
| 引用数 | 1 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 16 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm4539 |