Reference - Detail
| RRC ID | 55868 |
|---|---|
| Author | Chitturi J, Hung W, Rahman AMA, Wu M, Lim MA, Calarco J, Baran R, Huang X, Dennis JW, Zhen M. |
| Title | The UBR-1 ubiquitin ligase regulates glutamate metabolism to generate coordinated motor pattern in Caenorhabditis elegans. |
| Journal | PLoS Genet |
| Abstract |
UBR1 is an E3 ubiquitin ligase best known for its ability to target protein degradation by the N-end rule. The physiological functions of UBR family proteins, however, remain not fully understood. We found that the functional loss of C. elegans UBR-1 leads to a specific motor deficit: when adult animals generate reversal movements, A-class motor neurons exhibit synchronized activation, preventing body bending. This motor deficit is rescued by removing GOT-1, a transaminase that converts aspartate to glutamate. Both UBR-1 and GOT-1 are expressed and critically required in premotor interneurons of the reversal motor circuit to regulate the motor pattern. ubr-1 and got-1 mutants exhibit elevated and decreased glutamate level, respectively. These results raise an intriguing possibility that UBR proteins regulate glutamate metabolism, which is critical for neuronal development and signaling. |
| Volume | 14(4) |
| Pages | e1007303 |
| Published | 2018-4-1 |
| DOI | 10.1371/journal.pgen.1007303 |
| PII | PGENETICS-D-17-02069 |
| PMID | 29649217 |
| PMC | PMC5931689 |
| MeSH | Animals Caenorhabditis elegans / enzymology Caenorhabditis elegans / genetics Caenorhabditis elegans / physiology* Caenorhabditis elegans Proteins Glutamic Acid / metabolism* Motor Neurons / physiology Movement* Ubiquitin-Protein Ligases / genetics Ubiquitin-Protein Ligases / metabolism* |
| IF | 5.224 |
| Times Cited | 1 |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 10 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| C.elegans | tm2311 tm3424 tm2997 tm3233 tm3788 tm4283 |