論文 - 詳細
| RRC ID | 55903 |
|---|---|
| 著者 | Hirose Y, Onishi T, Miura S, Hatazawa Y, Kamei Y. |
| タイトル | Vitamin D Attenuates FOXO1-Target Atrophy Gene Expression in C2C12 Muscle Cells. |
| ジャーナル | J Nutr Sci Vitaminol (Tokyo) |
| Abstract |
Vitamin D is known to be effective for the prevention of muscle atrophy, such as age-related sarcopenia. However, vitamin D action in skeletal muscle tissue and muscle cells is largely unknown. We previously found that a transcription factor, FOXO1 gene expression, was induced in various muscle atrophy conditions causing muscle atrophy by upregulating atrophy-related genes, including atrogin 1 (ubiquitin ligase) and cathepsin L (lysosomal proteinase). In this study, we found that vitamin D inhibited FOXO1-mediated transcriptional activity in a reporter gene assay. Moreover, vitamin D suppressed the glucocorticoid-induced gene expression of atrogin 1 and cathepsin L in C2C12 myoblasts. Thus, vitamin D may prevent muscle atrophy via the FOXO1-mediated pathway in muscle cells. |
| 巻・号 | 64(3) |
| ページ | 229-232 |
| 公開日 | 2018-1-1 |
| DOI | 10.3177/jnsv.64.229 |
| PMID | 29962435 |
| MeSH | Animals Calcitriol / pharmacology Cathepsin L / genetics Forkhead Box Protein O1 / genetics* Gene Expression / drug effects* Glucocorticoids / pharmacology HEK293 Cells Humans Mice Muscular Atrophy / genetics* Muscular Atrophy / prevention & control Myoblasts / drug effects Myoblasts / metabolism* Receptors, Calcitriol / genetics SKP Cullin F-Box Protein Ligases / genetics Signal Transduction / drug effects Transcription, Genetic / drug effects Vitamin D / pharmacology* |
| IF | 1.125 |
| 引用数 | 3 |
| リソース情報 | |
| ヒト・動物細胞 | 293T(RCB2202) |