RRC ID 55909
Author Hamaoka Y, Negishi M, Katoh H.
Title Tyrosine kinase activity of EphA2 promotes its S897 phosphorylation and glioblastoma cell proliferation.
Journal Biochem Biophys Res Commun
Abstract EphA2, a member of the Eph family of receptor tyrosine kinases, has been reported to promote tumor malignancy through phosphorylation of serine 897 (S897). Here, we found that overexpression of wild-type EphA2 induced S897 phosphorylation through ERK activation without growth factors or cytokines and promoted glioblastoma cell proliferation. However, overexpression of a kinase-inactive mutant of EphA2 failed to induce ERK activation, S897 phosphorylation, and promotion of glioblastoma cell proliferation. These data suggest that when overexpressed, EphA2 induces ERK activation through its tyrosine kinase activity, leading to S897 phosphorylation and promotion of glioblastoma cell proliferation. Our findings provide a new insight into how EphA2 mediates glioblastoma progression.
Volume 499(4)
Pages 920-926
Published 2018-5-23
DOI 10.1016/j.bbrc.2018.04.020
PII S0006-291X(18)30783-6
PMID 29626472
MeSH Cell Line, Tumor Cell Proliferation Enzyme Activation Extracellular Signal-Regulated MAP Kinases / metabolism Glioblastoma / enzymology* Glioblastoma / pathology* Humans Models, Biological Phosphorylation Phosphoserine / metabolism* Receptor, EphA2 / metabolism*
IF 2.705
Times Cited 6
Resource
Human and Animal Cells A172(RCB2530)