RRC ID 56023
Author Daigo K, Takano A, Thang PM, Yoshitake Y, Shinohara M, Tohnai I, Murakami Y, Maegawa J, Daigo Y.
Title Characterization of KIF11 as a novel prognostic biomarker and therapeutic target for oral cancer.
Journal Int J Oncol
Abstract Oral cancer has a high mortality rate, and its incidence is increasing gradually worldwide. As the effectiveness of standard treatments is still limited, the development of new therapeutic strategies is eagerly awaited. Kinesin family member 11 (KIF11) is a motor protein required for establishing a bipolar spindle in cell division. The role of KIF11 in oral cancer is unclear. Therefore, the present study aimed to assess the role of KIF11 in oral cancer and evaluate its role as a prognostic biomarker and therapeutic target for treating oral cancer. Immunohistochemical analysis demonstrated that KIF11 was expressed in 64 of 99 (64.6%) oral cancer tissues but not in healthy oral epithelia. Strong KIF11 expression was significantly associated with poor prognosis among oral cancer patients (P=0.034), and multivariate analysis confirmed its independent prognostic value. In addition, inhibition of KIF11 expression by transfection of siRNAs into oral cancer cells or treatment of cells with a KIF11 inhibitor significantly suppressed cell proliferation, probably through G2/M arrest and subsequent induction of apoptosis. These results suggest that KIF11 could be a potential prognostic biomarker and therapeutic target for oral cancer.
Volume 52(1)
Pages 155-165
Published 2018-1
DOI 10.3892/ijo.2017.4181
PMID 29115586
PMC PMC5743338
MeSH Aged Apoptosis / physiology Benzamides / pharmacology Biomarkers, Tumor / biosynthesis Biomarkers, Tumor / genetics Cell Growth Processes / physiology Cell Line, Tumor Chromones / pharmacology Female Gene Knockdown Techniques Humans Immunohistochemistry Keratinocytes / enzymology Kinesin / antagonists & inhibitors Kinesin / biosynthesis* Kinesin / genetics Male Middle Aged Mouth Neoplasms / enzymology* Mouth Neoplasms / genetics Mouth Neoplasms / pathology Prognosis Tissue Array Analysis
IF 3.571
Times Cited 12
Human and Animal Cells HSC-3(RCB1975) HSC-4(RCB1902)