Reference - Detail
| RRC ID | 56092 |
|---|---|
| Author | Miyatake Y, Yamano T, Hanayama R. |
| Title | Myoferlin-Mediated Lysosomal Exocytosis Regulates Cytotoxicity by Phagocytes. |
| Journal | J Immunol |
| Abstract |
During inflammation, phagocytes release digestive enzymes from lysosomes to degrade harmful cells such as pathogens and tumor cells. However, the molecular mechanisms regulating this process are poorly understood. In this study, we identified myoferlin as a critical regulator of lysosomal exocytosis by mouse phagocytes. Myoferlin is a type II transmembrane protein with seven C2 domains in the cytoplasmic region. It localizes to lysosomes and mediates their fusion with the plasma membrane upon calcium stimulation. Myoferlin promotes the release of lysosomal contents, including hydrolytic enzymes, which increase cytotoxicity. These data demonstrate myoferlin's critical role in lysosomal exocytosis by phagocytes, providing novel insights into the mechanisms of inflammation-related cellular injuries. |
| Volume | 201(10) |
| Pages | 3051-3057 |
| Published | 2018-11-15 |
| DOI | 10.4049/jimmunol.1800268 |
| PII | jimmunol.1800268 |
| PMID | 30333125 |
| MeSH | Animals Cytotoxicity, Immunologic / immunology* Exocytosis / immunology Lysosomes / immunology Lysosomes / metabolism* Membrane Proteins / immunology Membrane Proteins / metabolism* Mice Mice, Inbred C57BL Muscle Proteins / immunology Muscle Proteins / metabolism* NIH 3T3 Cells Phagocytes / immunology Phagocytes / metabolism* |
| IF | 4.718 |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | News |
| Total number of mentions | 3 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Human and Animal Cells | NIH3T3 |