RRC ID 56171
Author Horspool AM, Chang HC.
Title Neuron-specific regulation of superoxide dismutase amid pathogen-induced gut dysbiosis.
Journal Redox Biol
Abstract Superoxide dismutase, an enzyme that converts superoxide into less-toxic hydrogen peroxide and oxygen, has been shown to mediate behavioral response to pathogens. However, it remains largely unknown how superoxide dismutase is regulated in the nervous system amid pathogen-induced gut dysbiosis. Although there are five superoxide dismutases in C. elegans, our genetic analyses suggest that SOD-1 is the primary superoxide dismutase to mediate the pathogen avoidance response. When C. elegans are fed a P. aeruginosa diet, the lack of SOD-1 contributes to enhanced lethality. We found that guanylyl cyclases GCY-5 and GCY-22 and neuropeptide receptor NPR-1 act antagonistically to regulate SOD-1 expression in the gustatory neuron ASER. After C. elegans ingests a diet that contributes to high levels of oxidative stress, the temporal regulation of SOD-1 and the SOD-1-dependent response in the gustatory system demonstrates a sophisticated mechanism to fine-tune behavioral plasticity. Our results may provide the initial glimpse of a strategy by which a multicellular organism copes with oxidative stress amid gut dysbiosis.
Volume 17
Pages 377-385
Published 2018-7-1
DOI 10.1016/j.redox.2018.05.007
PII S2213-2317(18)30366-5
PMID 29857312
PMC PMC6007053
MeSH Animals Caenorhabditis elegans / enzymology Caenorhabditis elegans / genetics Caenorhabditis elegans / microbiology Caenorhabditis elegans Proteins / genetics* Caenorhabditis elegans Proteins / metabolism Dysbiosis / enzymology Dysbiosis / genetics* Dysbiosis / microbiology Gastrointestinal Microbiome / genetics Gene Expression Regulation, Enzymologic Guanylate Cyclase / genetics Mutation Neurons / metabolism Neurons / microbiology Neurons / pathology Oxidative Stress / genetics* Pseudomonas aeruginosa / metabolism Pseudomonas aeruginosa / pathogenicity Receptors, Neuropeptide Y / genetics* Receptors, Neuropeptide Y / metabolism Superoxide Dismutase / genetics* Superoxide Dismutase / metabolism Taste / genetics
IF 7.793
Times Cited 2
C.elegans tm897 tm2364