論文 - 詳細
| RRC ID | 56171 |
|---|---|
| 著者 | Horspool AM, Chang HC. |
| タイトル | Neuron-specific regulation of superoxide dismutase amid pathogen-induced gut dysbiosis. |
| ジャーナル | Redox Biol |
| Abstract |
Superoxide dismutase, an enzyme that converts superoxide into less-toxic hydrogen peroxide and oxygen, has been shown to mediate behavioral response to pathogens. However, it remains largely unknown how superoxide dismutase is regulated in the nervous system amid pathogen-induced gut dysbiosis. Although there are five superoxide dismutases in C. elegans, our genetic analyses suggest that SOD-1 is the primary superoxide dismutase to mediate the pathogen avoidance response. When C. elegans are fed a P. aeruginosa diet, the lack of SOD-1 contributes to enhanced lethality. We found that guanylyl cyclases GCY-5 and GCY-22 and neuropeptide receptor NPR-1 act antagonistically to regulate SOD-1 expression in the gustatory neuron ASER. After C. elegans ingests a diet that contributes to high levels of oxidative stress, the temporal regulation of SOD-1 and the SOD-1-dependent response in the gustatory system demonstrates a sophisticated mechanism to fine-tune behavioral plasticity. Our results may provide the initial glimpse of a strategy by which a multicellular organism copes with oxidative stress amid gut dysbiosis. |
| 巻・号 | 17 |
| ページ | 377-385 |
| 公開日 | 2018-7-1 |
| DOI | 10.1016/j.redox.2018.05.007 |
| PII | S2213-2317(18)30366-5 |
| PMID | 29857312 |
| PMC | PMC6007053 |
| MeSH | Animals Caenorhabditis elegans / enzymology Caenorhabditis elegans / genetics Caenorhabditis elegans / microbiology Caenorhabditis elegans Proteins / genetics* Caenorhabditis elegans Proteins / metabolism Dysbiosis / enzymology Dysbiosis / genetics* Dysbiosis / microbiology Gastrointestinal Microbiome / genetics Gene Expression Regulation, Enzymologic Guanylate Cyclase / genetics Mutation Neurons / metabolism Neurons / microbiology Neurons / pathology Oxidative Stress / genetics* Pseudomonas aeruginosa / metabolism Pseudomonas aeruginosa / pathogenicity Receptors, Neuropeptide Y / genetics* Receptors, Neuropeptide Y / metabolism Superoxide Dismutase / genetics* Superoxide Dismutase / metabolism Taste / genetics |
| IF | 7.793 |
| 引用数 | 2 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 4 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm897 tm2364 |