RRC ID 56217
Author Saldi TK, Gonzales P, Garrido-Lecca A, Dostal V, Roberts CM, Petrucelli L, Link CD.
Title The Caenorhabditis elegans Ortholog of TDP-43 Regulates the Chromatin Localization of the Heterochromatin Protein 1 Homolog HPL-2.
Journal Mol. Cell. Biol.
Abstract deletion strain, consistent with HPL-2 acting in consort with TDP-1 to modulate these aspects of RNA metabolism. Our observations identify novel mechanisms by which HP1 homologs can be recruited to chromatin and by which nuclear depletion of human TDP-43 may lead to changes in RNA metabolism that are relevant to disease.
Volume 38(15)
Published 2018-8-1
DOI 10.1128/MCB.00668-17
PII MCB.00668-17
PMID 29760282
IF 3.813
Resource
C.elegans tm1116 tm1489