論文 - 詳細
| RRC ID | 56230 |
|---|---|
| 著者 | Ujisawa T, Ohta A, Ii T, Minakuchi Y, Toyoda A, Ii M, Kuhara A. |
| タイトル | Endoribonuclease ENDU-2 regulates multiple traits including cold tolerance via cell autonomous and nonautonomous controls in Caenorhabditis elegans. |
| ジャーナル | Proc Natl Acad Sci U S A |
| Abstract |
Environmental temperature acclimation is essential to animal survival, yet thermoregulation mechanisms remain poorly understood. We demonstrate cold tolerance in Caenorhabditis elegans as regulated by paired ADL chemosensory neurons via Ca2+-dependent endoribonuclease (EndoU) ENDU-2. Loss of ENDU-2 function results in life span, brood size, and synaptic remodeling abnormalities in addition to enhanced cold tolerance. Enzymatic ENDU-2 defects localized in the ADL and certain muscle cells led to increased cold tolerance in endu-2 mutants. Ca2+ imaging revealed ADL neurons were responsive to temperature stimuli through transient receptor potential (TRP) channels, concluding that ADL function requires ENDU-2 action in both cell-autonomous and cell-nonautonomous mechanisms. ENDU-2 is involved in caspase expression, which is central to cold tolerance and synaptic remodeling in dorsal nerve cord. We therefore conclude that ENDU-2 regulates cell type-dependent, cell-autonomous, and cell-nonautonomous cold tolerance. |
| 巻・号 | 115(35) |
| ページ | 8823-8828 |
| 公開日 | 2018-8-28 |
| DOI | 10.1073/pnas.1808634115 |
| PII | 1808634115 |
| PMID | 30104389 |
| PMC | PMC6126727 |
| MeSH | Acclimatization / physiology* Animals Caenorhabditis elegans / enzymology* Caenorhabditis elegans / genetics Caenorhabditis elegans Proteins / biosynthesis Caenorhabditis elegans Proteins / genetics Caspases / biosynthesis Caspases / genetics Endoribonucleases / genetics Endoribonucleases / metabolism* Gene Expression Profiling Quantitative Trait, Heritable* Signal Transduction / physiology* Synapses / genetics Synapses / metabolism* TRPC Cation Channels / genetics TRPC Cation Channels / metabolism |
| IF | 9.58 |
| 引用数 | 7 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 7 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm4977 tm2644 tm1099 |