Reference - Detail
| RRC ID | 56231 |
|---|---|
| Author | Verma S, Jagtap U, Goyala A, Mukhopadhyay A. |
| Title | A novel gene-diet pair modulates C. elegans aging. |
| Journal | PLoS Genet |
| Abstract |
Diet profoundly affects metabolism and incidences of age-related diseases. Animals adapt their physiology to different food-types, modulating complex life-history traits like aging. The molecular mechanisms linking adaptive capacity to diet with aging are less known. We identify FLR-4 kinase as a novel modulator of aging in C. elegans, depending on bacterial diet. FLR-4 functions to prevent differential activation of the p38MAPK pathway in response to diverse food-types, thereby maintaining normal life span. In a kinase-dead flr-4 mutant, E. coli HT115 (K12 strain), but not the standard diet OP50 (B strain), is able to activate p38MAPK, elevate expression of cytoprotective genes through the nuclear hormone receptor NHR-8 and enhance life span. Interestingly, flr-4 and dietary restriction utilize similar pathways for longevity assurance, suggesting cross-talks between cellular modules that respond to diet quality and quantity. Together, our study discovers a new C. elegans gene-diet pair that controls the plasticity of aging. |
| Volume | 14(8) |
| Pages | e1007608 |
| Published | 2018-8-1 |
| DOI | 10.1371/journal.pgen.1007608 |
| PII | PGENETICS-D-17-01992 |
| PMID | 30125273 |
| PMC | PMC6117094 |
| MeSH | Aging / genetics* Animals Caenorhabditis elegans / physiology* Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / physiology* Diet* Gene Expression Regulation Longevity Protein Serine-Threonine Kinases / genetics Protein Serine-Threonine Kinases / physiology* RNA, Helminth / genetics Receptors, Cytoplasmic and Nuclear / genetics Receptors, Cytoplasmic and Nuclear / physiology Signal Transduction Transcriptome p38 Mitogen-Activated Protein Kinases / physiology |
| IF | 5.224 |
| Times Cited | 2 |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 13 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| C.elegans | tm3036 |