| RRC ID |
56266
|
| 著者 |
Hara Y, Arai MA, Toume K, Masu H, Sato T, Komatsu K, Yaguchi T, Ishibashi M.
|
| タイトル |
Coculture of a Pathogenic Actinomycete and Animal Cells To Produce Nocarjamide, a Cyclic Nonapeptide with Wnt Signal-Activating Effect.
|
| ジャーナル |
Org Lett
|
| Abstract |
A coculture method with a pathogenic actinomycete of the genus Nocardia and an animal cell line was designed to reconstruct and emulate the initial infection state, and a new cyclic nonapeptide, named nocarjamide (1), was obtained by coculture of Nocardia tenerifensis IFM 10554T and the mouse macrophage-like cell line J774.1 in a modified Czapek-Dox medium. Nocarjamide (1) exhibited Wnt signal-activating effects.
|
| 巻・号 |
20(18)
|
| ページ |
5831-5834
|
| 公開日 |
2018-9-21
|
| DOI |
10.1021/acs.orglett.8b02522
|
| PMID |
30156858
|
| MeSH |
Animals
Cell Line
Cell Survival / drug effects
Coculture Techniques*
HEK293 Cells
Humans
Mice
Molecular Conformation
Nocardia / chemistry
Nocardia / growth & development
Nocardia / metabolism*
Peptides, Cyclic / chemistry
Peptides, Cyclic / genetics
Peptides, Cyclic / metabolism*
Wnt Signaling Pathway / drug effects
|
| IF |
6.555
|
| 引用数 |
4
|
| リソース情報 |
| 病原真核微生物 |
病原放線菌：IFM 10554 |
