論文 - 詳細
| RRC ID | 56266 |
|---|---|
| 著者 | Hara Y, Arai MA, Toume K, Masu H, Sato T, Komatsu K, Yaguchi T, Ishibashi M. |
| タイトル | Coculture of a Pathogenic Actinomycete and Animal Cells To Produce Nocarjamide, a Cyclic Nonapeptide with Wnt Signal-Activating Effect. |
| ジャーナル | Org Lett |
| Abstract |
A coculture method with a pathogenic actinomycete of the genus Nocardia and an animal cell line was designed to reconstruct and emulate the initial infection state, and a new cyclic nonapeptide, named nocarjamide (1), was obtained by coculture of Nocardia tenerifensis IFM 10554T and the mouse macrophage-like cell line J774.1 in a modified Czapek-Dox medium. Nocarjamide (1) exhibited Wnt signal-activating effects. |
| 巻・号 | 20(18) |
| ページ | 5831-5834 |
| 公開日 | 2018-9-21 |
| DOI | 10.1021/acs.orglett.8b02522 |
| PMID | 30156858 |
| MeSH | Animals Cell Line Cell Survival / drug effects Coculture Techniques* HEK293 Cells Humans Mice Molecular Conformation Nocardia / chemistry Nocardia / growth & development Nocardia / metabolism* Peptides, Cyclic / chemistry Peptides, Cyclic / genetics Peptides, Cyclic / metabolism* Wnt Signaling Pathway / drug effects |
| IF | 6.555 |
| 引用数 | 4 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 病原真核微生物 | 病原放線菌：IFM 10554 |