論文 - 詳細
| RRC ID | 56897 |
|---|---|
| 著者 | Matsumoto Y, Ishii M, Sekimizu K. |
| タイトル | An in vivo invertebrate evaluation system for identifying substances that suppress sucrose-induced postprandial hyperglycemia. |
| ジャーナル | Sci Rep |
| Abstract |
Sucrose is a major sweetener added to various foods and beverages. Excessive intake of sucrose leads to increases in blood glucose levels, which can result in the development and exacerbation of lifestyle-related diseases such as obesity and diabetes. In this study, we established an in vivo evaluation system using silkworms to explore substances that suppress the increase in blood glucose levels caused by dietary intake of sucrose. Silkworm hemolymph glucose levels rapidly increased after intake of a sucrose-containing diet. Addition of acarbose or voglibose, α-glycosidase inhibitors clinically used for diabetic patients, suppressed the dietary sucrose-induced increase in the silkworm hemolymph glucose levels. Screening performed using the sucrose-induced postprandial hyperglycemic silkworm model allowed us to identify some lactic acid bacteria that inhibit the increase in silkworm hemolymph glucose levels caused by dietary intake of sucrose. The inhibitory effects of the Lactococcus lactis #Ll-1 bacterial strain were significantly greater than those of different strains of lactic acid bacteria. No effect of the Lactococcus lactis #Ll-1 strain was observed in silkworms fed a glucose diet. These results suggest that the sucrose diet-induced postprandial hyperglycemic silkworm is a useful model for evaluating chemicals and lactic acid bacteria that suppress increases in blood glucose levels. |
| 巻・号 | 6 |
| ページ | 26354 |
| 公開日 | 2016-5-19 |
| DOI | 10.1038/srep26354 |
| PII | srep26354 |
| PMID | 27194587 |
| PMC | PMC4872229 |
| MeSH | Acarbose / administration & dosage Acarbose / pharmacology Animals Bombyx / metabolism* Bombyx / microbiology Dietary Sucrose / adverse effects* Disease Models, Animal Glucose / metabolism Glycoside Hydrolase Inhibitors / administration & dosage* Glycoside Hydrolase Inhibitors / pharmacology Hemolymph / metabolism Hemolymph / microbiology Humans Hyperglycemia / chemically induced* Hyperglycemia / drug therapy* Inositol / administration & dosage Inositol / analogs & derivatives Inositol / pharmacology Lactobacillales / classification Lactobacillales / drug effects Lactobacillales / isolation & purification Phylogeny Postprandial Period |
| IF | 4.011 |
| 引用数 | 13 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| カイコ | |