RRC ID 5693
Author Nakayama M, Maruyama S, Kanda H, Ohkita N, Nakano K, Ito F, Kawasaki K.
Title Relationships of Drosophila melanogaster RECQ5/QE to cell-cycle progression and DNA damage.
Journal FEBS Lett.
Abstract Members of the RecQ family of DNA helicases are involved in the cellular response to DNA damage and are regulated in the cell-cycle. However, little is known about RecQ5, one of these members. The level of RECQ5/QE, Drosophila melanogaster RecQ5, was increased after the exposure of cultured cells to methyl-methanesulfonate. Transgenic flies that overexpressed RECQ5/QE in their developing eye primordia showed mild roughening of the ommatidial lattice. DNA-damaging agents and the mei-41 mutation enhanced the phenotype caused by RECQ5/QE overexpression. Overexpression of RECQ5/QE perturbed the progression of the cell-cycle in response to DNA damage in the eye imaginal discs. These results suggest that RECQ5/QE interacts with components of the cell-cycle during its progression in response to DNA damage.
Volume 580(30)
Pages 6938-42
Published 2006-12-22
DOI 10.1016/j.febslet.2006.11.059
PII S0014-5793(06)01400-1
PMID 17157839
MeSH Animals Cell Cycle* Cell Line DNA Damage / genetics* Drosophila melanogaster / cytology Drosophila melanogaster / enzymology* Drosophila melanogaster / genetics* Eye / cytology Eye / metabolism Gene Expression Regulation, Enzymologic Microscopy, Electron, Scanning Phenotype RecQ Helicases / genetics RecQ Helicases / metabolism*
IF 2.675
Times Cited 6
Drosophila DGRC#107531 DGRC#107532