論文 - 詳細
| RRC ID | 57102 |
|---|---|
| 著者 | Tian A, Duwadi D, Benchabane H, Ahmed Y. |
| タイトル | Essential long-range action of Wingless/Wnt in adult intestinal compartmentalization. |
| ジャーナル | PLoS Genet |
| Abstract |
Signal transduction activated by Wingless/Wnt ligands directs cell proliferation and fate specification in metazoans, and its overactivation underlies the development of the vast majority of colorectal cancers. In the conventional model, the secretion and movement of Wingless to cells distant from its source of synthesis are essential for long-range signaling in tissue patterning. However, this model was upended recently by an unanticipated finding: replacement of wild-type Drosophila Wingless with a membrane-tethered form produced viable adults with largely normal external morphology, which suggested that Wingless secretion and movement are dispensable for tissue patterning. Herein, we tested this foundational principle in the adult intestine, where Wingless signaling gradients coincide with all major boundaries between compartments. We find that the critical roles of Wingless during adult intestinal development, which include regulation of target gene activation, boundary formation, stem cell proliferation, epithelial cell fate specification, muscle differentiation, gut folding, and signaling crosstalk with the Decapentaplegic pathway, are all disrupted by Wingless tethering. These findings provide new evidence that supports the requirement for the direct, long-range action of Wingless in tissue patterning, with relevance for animal development, tissue homeostasis and Wnt-driven disease. |
| 巻・号 | 15(6) |
| ページ | e1008111 |
| 公開日 | 2019-6-1 |
| DOI | 10.1371/journal.pgen.1008111 |
| PII | PGENETICS-D-18-01420 |
| PMID | 31194729 |
| PMC | PMC6563961 |
| MeSH | Animals Body Patterning / genetics* Cell Differentiation / genetics Cell Lineage / genetics Cell Proliferation / genetics Drosophila Proteins / genetics* Drosophila melanogaster / genetics* Drosophila melanogaster / growth & development Epithelial Cells / cytology Epithelial Cells / metabolism Gene Expression Regulation, Developmental / genetics Homeostasis Intestines / growth & development Signal Transduction / genetics Stem Cells / metabolism Wnt1 Protein / genetics* |
| IF | 5.224 |
| 引用数 | 7 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 11 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | DGRC#113273 |