論文 - 詳細
| RRC ID | 57146 |
|---|---|
| 著者 | Goda T, Doi M, Umezaki Y, Murai I, Shimatani H, Chu ML, Nguyen VH, Okamura H, Hamada FN. |
| タイトル | Calcitonin receptors are ancient modulators for rhythms of preferential temperature in insects and body temperature in mammals. |
| ジャーナル | Genes Dev |
| Abstract |
Daily body temperature rhythm (BTR) is essential for maintaining homeostasis. BTR is regulated separately from locomotor activity rhythms, but its molecular basis is largely unknown. While mammals internally regulate BTR, ectotherms, including Drosophila, exhibit temperature preference rhythm (TPR) behavior to regulate BTR. Here, we demonstrate that the diuretic hormone 31 receptor (DH31R) mediates TPR during the active phase in Drosophila DH31R is expressed in clock cells, and its ligand, DH31, acts on clock cells to regulate TPR during the active phase. Surprisingly, the mouse homolog of DH31R, calcitonin receptor (Calcr), is expressed in the suprachiasmatic nucleus (SCN) and mediates body temperature fluctuations during the active phase in mice. Importantly, DH31R and Calcr are not required for coordinating locomotor activity rhythms. Our results represent the first molecular evidence that BTR is regulated distinctly from locomotor activity rhythms and show that DH31R/Calcr is an ancient specific mediator of BTR during the active phase in organisms ranging from ectotherms to endotherms. |
| 巻・号 | 32(2) |
| ページ | 140-155 |
| 公開日 | 2018-1-15 |
| DOI | 10.1101/gad.307884.117 |
| PII | gad.307884.117 |
| PMID | 29440246 |
| PMC | PMC5830927 |
| MeSH | Animals Body Temperature Regulation* Brain / metabolism Drosophila / genetics Drosophila / metabolism Drosophila Proteins / genetics Drosophila Proteins / metabolism Drosophila Proteins / physiology* Insect Hormones / physiology Locomotion Mice Mutation Neuropeptides / physiology Receptors, Calcitonin / metabolism Receptors, Calcitonin / physiology* Suprachiasmatic Nucleus / metabolism |
| IF | 8.99 |
| 引用数 | 8 |
| オルトメトリクス指標 |
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 34 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
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