| RRC ID |
57150
|
| Author |
Nagy O, Nuez I, Savisaar R, Peluffo AE, Yassin A, Lang M, Stern DL, Matute DR, David JR, Courtier-Orgogozo V.
|
| Title |
Correlated Evolution of Two Copulatory Organs via a Single cis-Regulatory Nucleotide Change.
|
| Journal |
Curr Biol
|
| Abstract |
Diverse traits often covary between species [1-3]. The possibility that a single mutation could contribute to the evolution of several characters between species [3] is rarely investigated as relatively few cases are dissected at the nucleotide level. Drosophila santomea has evolved additional sex comb sensory teeth on its legs and has lost two sensory bristles on its genitalia. We present evidence that a single nucleotide substitution in an enhancer of the scute gene contributes to both changes. The mutation alters a binding site for the Hox protein Abdominal-B in the developing genitalia, leading to bristle loss, and for another factor in the developing leg, leading to bristle gain. Our study suggests that morphological evolution between species can occur through a single nucleotide change affecting several sexually dimorphic traits. VIDEO ABSTRACT.
|
| Volume |
28(21)
|
| Pages |
3450-3457.e13
|
| Published |
2018-11-5
|
| DOI |
10.1016/j.cub.2018.08.047
|
| PII |
S0960-9822(18)31131-X
|
| PMID |
30344115
|
| PMC |
PMC7385753
|
| MeSH |
Animals
Binding Sites
Biological Evolution*
Drosophila / anatomy & histology*
Drosophila / genetics*
Drosophila Proteins / genetics*
Drosophila Proteins / metabolism
Evolution, Molecular
Gene Expression Regulation, Developmental*
Genitalia, Male / anatomy & histology
Homeodomain Proteins / genetics*
Homeodomain Proteins / metabolism
Male
Mutation
Nucleotides / genetics
|
| IF |
9.193
|
| Times Cited |
17
|
| Resource |
| Drosophila |
|
