論文 - 詳細
| RRC ID | 57242 |
|---|---|
| 著者 | Napoletano F, Gibert B, Yacobi-Sharon K, Vincent S, Favrot C, Mehlen P, Girard V, Teil M, Chatelain G, Walter L, Arama E, Mollereau B. |
| タイトル | p53-dependent programmed necrosis controls germ cell homeostasis during spermatogenesis. |
| ジャーナル | PLoS Genet |
| Abstract |
The importance of regulated necrosis in pathologies such as cerebral stroke and myocardial infarction is now fully recognized. However, the physiological relevance of regulated necrosis remains unclear. Here, we report a conserved role for p53 in regulating necrosis in Drosophila and mammalian spermatogenesis. We found that Drosophila p53 is required for the programmed necrosis that occurs spontaneously in mitotic germ cells during spermatogenesis. This form of necrosis involved an atypical function of the initiator caspase Dronc/Caspase 9, independent of its catalytic activity. Prevention of p53-dependent necrosis resulted in testicular hyperplasia, which was reversed by restoring necrosis in spermatogonia. In mouse testes, p53 was required for heat-induced germ cell necrosis, indicating that regulation of necrosis is a primordial function of p53 conserved from invertebrates to vertebrates. Drosophila and mouse spermatogenesis will thus be useful models to identify inducers of necrosis to treat cancers that are refractory to apoptosis. |
| 巻・号 | 13(9) |
| ページ | e1007024 |
| 公開日 | 2017-9-1 |
| DOI | 10.1371/journal.pgen.1007024 |
| PII | PGENETICS-D-17-00954 |
| PMID | 28945745 |
| PMC | PMC5629030 |
| MeSH | Animals Apoptosis / genetics Caspase 9 / genetics Caspases / genetics Disease Models, Animal Drosophila Proteins / genetics Drosophila melanogaster / genetics Drosophila melanogaster / growth & development Germ Cells / growth & development Germ Cells / pathology Homeostasis / genetics Humans Hyperplasia / genetics Hyperplasia / pathology Male Mice Necrosis / genetics* Necrosis / pathology Spermatogenesis / genetics* Testis / growth & development Testis / metabolism Tumor Suppressor Protein p53 / genetics* |
| IF | 5.224 |
| 引用数 | 16 |
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 5 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
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