論文 - 詳細
| RRC ID | 57289 |
|---|---|
| 著者 | Catrina IE, Bayer LV, Yanez G, McLaughlin JM, Malaczek K, Bagaeva E, Marras SA, Bratu DP. |
| タイトル | The temporally controlled expression of Drongo, the fruit fly homolog of AGFG1, is achieved in female germline cells via P-bodies and its localization requires functional Rab11. |
| ジャーナル | RNA Biol |
| Abstract |
To achieve proper RNA transport and localization, RNA viruses exploit cellular vesicular trafficking pathways. AGFG1, a host protein essential for HIV-1 and Influenza A replication, has been shown to mediate release of intron-containing viral RNAs from the perinuclear region. It is still unknown what its precise role in this release is, or whether AGFG1 also participates in cytoplasmic transport. We report for the first time the expression patterns during oogenesis for Drongo, the fruit fly homolog of AGFG1. We find that temporally controlled Drongo expression is achieved by translational repression of drongo mRNA within P-bodies. Here we show a first link between the recycling endosome pathway and Drongo, and find that proper Drongo localization at the oocyte's cortex during mid-oogenesis requires functional Rab11. |
| 巻・号 | 13(11) |
| ページ | 1117-1132 |
| 公開日 | 2016-11-1 |
| DOI | 10.1080/15476286.2016.1218592 |
| PMID | 27654348 |
| PMC | PMC5100350 |
| MeSH | Animals Drosophila / genetics Drosophila / metabolism Drosophila / physiology* Drosophila Proteins / genetics Drosophila Proteins / metabolism* Endosomes / metabolism Female Gene Expression Regulation Microfilament Proteins / genetics Microfilament Proteins / metabolism* Oocytes / cytology* Oocytes / metabolism Oogenesis Protein Transport rab GTP-Binding Proteins / metabolism* |
| IF | 5.477 |
| 引用数 | 3 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | DGRC#123365 DGRC#125008 DGRC#115460 |