RRC ID 57289
Author Catrina IE, Bayer LV, Yanez G, McLaughlin JM, Malaczek K, Bagaeva E, Marras SA, Bratu DP.
Title The temporally controlled expression of Drongo, the fruit fly homolog of AGFG1, is achieved in female germline cells via P-bodies and its localization requires functional Rab11.
Journal RNA Biol
Abstract To achieve proper RNA transport and localization, RNA viruses exploit cellular vesicular trafficking pathways. AGFG1, a host protein essential for HIV-1 and Influenza A replication, has been shown to mediate release of intron-containing viral RNAs from the perinuclear region. It is still unknown what its precise role in this release is, or whether AGFG1 also participates in cytoplasmic transport. We report for the first time the expression patterns during oogenesis for Drongo, the fruit fly homolog of AGFG1. We find that temporally controlled Drongo expression is achieved by translational repression of drongo mRNA within P-bodies. Here we show a first link between the recycling endosome pathway and Drongo, and find that proper Drongo localization at the oocyte's cortex during mid-oogenesis requires functional Rab11.
Volume 13(11)
Pages 1117-1132
Published 2016-11
DOI 10.1080/15476286.2016.1218592
PMID 27654348
PMC PMC5100350
MeSH Animals Drosophila / genetics Drosophila / metabolism Drosophila / physiology* Drosophila Proteins / genetics Drosophila Proteins / metabolism* Endosomes / metabolism Female Gene Expression Regulation Microfilament Proteins / genetics Microfilament Proteins / metabolism* Oocytes / cytology* Oocytes / metabolism Oogenesis Protein Transport rab GTP-Binding Proteins / metabolism*
IF 5.477
Times Cited 3
Resource
Drosophila DGRC#123365 DGRC#125008 DGRC#115460