| RRC ID |
57289
|
| 著者 |
Catrina IE, Bayer LV, Yanez G, McLaughlin JM, Malaczek K, Bagaeva E, Marras SA, Bratu DP.
|
| タイトル |
The temporally controlled expression of Drongo, the fruit fly homolog of AGFG1, is achieved in female germline cells via P-bodies and its localization requires functional Rab11.
|
| ジャーナル |
RNA Biol
|
| Abstract |
To achieve proper RNA transport and localization, RNA viruses exploit cellular vesicular trafficking pathways. AGFG1, a host protein essential for HIV-1 and Influenza A replication, has been shown to mediate release of intron-containing viral RNAs from the perinuclear region. It is still unknown what its precise role in this release is, or whether AGFG1 also participates in cytoplasmic transport. We report for the first time the expression patterns during oogenesis for Drongo, the fruit fly homolog of AGFG1. We find that temporally controlled Drongo expression is achieved by translational repression of drongo mRNA within P-bodies. Here we show a first link between the recycling endosome pathway and Drongo, and find that proper Drongo localization at the oocyte's cortex during mid-oogenesis requires functional Rab11.
|
| 巻・号 |
13(11)
|
| ページ |
1117-1132
|
| 公開日 |
2016-11-1
|
| DOI |
10.1080/15476286.2016.1218592
|
| PMID |
27654348
|
| PMC |
PMC5100350
|
| MeSH |
Animals
Drosophila / genetics
Drosophila / metabolism
Drosophila / physiology*
Drosophila Proteins / genetics
Drosophila Proteins / metabolism*
Endosomes / metabolism
Female
Gene Expression Regulation
Microfilament Proteins / genetics
Microfilament Proteins / metabolism*
Oocytes / cytology*
Oocytes / metabolism
Oogenesis
Protein Transport
rab GTP-Binding Proteins / metabolism*
|
| IF |
5.477
|
| 引用数 |
3
|
| リソース情報 |
| ショウジョウバエ |
DGRC#123365
DGRC#125008
DGRC#115460 |
