論文 - 詳細
| RRC ID | 57360 |
|---|---|
| 著者 | Shimell M, Pan X, Martin FA, Ghosh AC, Leopold P, O'Connor MB, Romero NM. |
| タイトル | Prothoracicotropic hormone modulates environmental adaptive plasticity through the control of developmental timing. |
| ジャーナル | Development |
| Abstract |
Adult size and fitness are controlled by a combination of genetics and environmental cues. In Drosophila, growth is confined to the larval phase and final body size is impacted by the duration of this phase, which is under neuroendocrine control. The neuropeptide prothoracicotropic hormone (PTTH) has been proposed to play a central role in controlling the length of the larval phase through regulation of ecdysone production, a steroid hormone that initiates larval molting and metamorphosis. Here, we test this by examining the consequences of null mutations in the Ptth gene for Drosophila development. Loss of Ptth causes several developmental defects, including a delay in developmental timing, increase in critical weight, loss of coordination between body and imaginal disc growth, and reduced adult survival in suboptimal environmental conditions such as nutritional deprivation or high population density. These defects are caused by a decrease in ecdysone production associated with altered transcription of ecdysone biosynthetic genes. Therefore, the PTTH signal contributes to coordination between environmental cues and the developmental program to ensure individual fitness and survival. |
| 巻・号 | 145(6) |
| 公開日 | 2018-3-14 |
| DOI | 10.1242/dev.159699 |
| PII | dev.159699 |
| PMID | 29467242 |
| PMC | PMC5897599 |
| MeSH | Adaptation, Physiological / genetics* Adaptation, Physiological / physiology Animals Cell Plasticity / genetics Cell Plasticity / physiology* Cues Drosophila / genetics Drosophila / growth & development* Drosophila / physiology Drosophila Proteins / metabolism Ecdysone / biosynthesis Environment Immunohistochemistry Insect Hormones / genetics Insect Hormones / physiology* Larva / metabolism Larva / physiology Metamorphosis, Biological / physiology Mutagenesis Real-Time Polymerase Chain Reaction Signal Transduction |
| IF | 5.763 |
| 引用数 | 13 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 11 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 5.0 |
| リソース情報 | |
| ショウジョウバエ | DGRC#103604 |