論文 - 詳細
| RRC ID | 57373 |
|---|---|
| 著者 | Groschner LN, Chan Wah Hak L, Bogacz R, DasGupta S, Miesenböck G. |
| タイトル | Dendritic Integration of Sensory Evidence in Perceptual Decision-Making. |
| ジャーナル | Cell |
| Abstract |
Perceptual decisions require the accumulation of sensory information to a response criterion. Most accounts of how the brain performs this process of temporal integration have focused on evolving patterns of spiking activity. We report that subthreshold changes in membrane voltage can represent accumulating evidence before a choice. αβ core Kenyon cells (αβc KCs) in the mushroom bodies of fruit flies integrate odor-evoked synaptic inputs to action potential threshold at timescales matching the speed of olfactory discrimination. The forkhead box P transcription factor (FoxP) sets neuronal integration and behavioral decision times by controlling the abundance of the voltage-gated potassium channel Shal (KV4) in αβc KC dendrites. αβc KCs thus tailor, through a particular constellation of biophysical properties, the generic process of synaptic integration to the demands of sequential sampling. |
| 巻・号 | 173(4) |
| ページ | 894-905.e13 |
| 公開日 | 2018-5-3 |
| DOI | 10.1016/j.cell.2018.03.075 |
| PII | S0092-8674(18)30447-1 |
| PMID | 29706545 |
| PMC | PMC5947940 |
| MeSH | Action Potentials / drug effects Animals Barium / pharmacology Behavior, Animal / drug effects Brain / metabolism Brain / pathology Cyclohexanols / pharmacology Dendrites / metabolism* Drosophila / physiology* Drosophila Proteins / genetics Drosophila Proteins / metabolism* Female Forkhead Transcription Factors / genetics Forkhead Transcription Factors / metabolism Male Neurons / cytology Neurons / metabolism Patch-Clamp Techniques Receptors, Odorant / metabolism Shal Potassium Channels / genetics Shal Potassium Channels / metabolism Smell Synapses / metabolism |
| IF | 36.216 |
| 引用数 | 14 |
| リソース情報 | |
| ショウジョウバエ | DGRC#105080 DGRC#114120 DGRC#126252 |