RRC ID 57373
Author Groschner LN, Chan Wah Hak L, Bogacz R, DasGupta S, Miesenböck G.
Title Dendritic Integration of Sensory Evidence in Perceptual Decision-Making.
Journal Cell
Abstract Perceptual decisions require the accumulation of sensory information to a response criterion. Most accounts of how the brain performs this process of temporal integration have focused on evolving patterns of spiking activity. We report that subthreshold changes in membrane voltage can represent accumulating evidence before a choice. αβ core Kenyon cells (αβc KCs) in the mushroom bodies of fruit flies integrate odor-evoked synaptic inputs to action potential threshold at timescales matching the speed of olfactory discrimination. The forkhead box P transcription factor (FoxP) sets neuronal integration and behavioral decision times by controlling the abundance of the voltage-gated potassium channel Shal (KV4) in αβc KC dendrites. αβc KCs thus tailor, through a particular constellation of biophysical properties, the generic process of synaptic integration to the demands of sequential sampling.
Volume 173(4)
Pages 894-905.e13
Published 2018-5-3
DOI 10.1016/j.cell.2018.03.075
PII S0092-8674(18)30447-1
PMID 29706545
PMC PMC5947940
MeSH Action Potentials / drug effects Animals Barium / pharmacology Behavior, Animal / drug effects Brain / metabolism Brain / pathology Cyclohexanols / pharmacology Dendrites / metabolism* Drosophila / physiology* Drosophila Proteins / genetics Drosophila Proteins / metabolism* Female Forkhead Transcription Factors / genetics Forkhead Transcription Factors / metabolism Male Neurons / cytology Neurons / metabolism Patch-Clamp Techniques Receptors, Odorant / metabolism Shal Potassium Channels / genetics Shal Potassium Channels / metabolism Smell Synapses / metabolism
IF 36.216
Times Cited 14
Drosophila DGRC#105080 DGRC#114120 DGRC#126252