論文 - 詳細
| RRC ID | 57399 |
|---|---|
| 著者 | Matsuno M, Horiuchi J, Yuasa Y, Ofusa K, Miyashita T, Masuda T, Saitoe M. |
| タイトル | Long-term memory formation in Drosophila requires training-dependent glial transcription. |
| ジャーナル | J Neurosci |
| Abstract |
Long-term memory (LTM) formation requires de novo gene expression in neurons, and subsequent structural and functional modification of synapses. However, the importance of gene expression in glia during this process has not been well studied. In this report, we characterize a cell adhesion molecule, Klingon (Klg), which is required for LTM formation in Drosophila. We found that Klg localizes to the juncture between neurons and glia, and expression in both cell types is required for LTM. We further found that expression of a glial gene, repo, is reduced in klg mutants and knockdown lines. repo expression is required for LTM, and expression increases upon LTM induction. In addition, increasing repo expression in glia is sufficient to restore LTM in klg knockdown lines. These data indicate that neuronal activity enhances Klg-mediated neuron-glia interactions, causing an increase in glial expression of repo. Repo is a homeodomain transcription factor, suggesting that further downstream glial gene expression is also required for LTM. |
| 巻・号 | 35(14) |
| ページ | 5557-65 |
| 公開日 | 2015-4-8 |
| DOI | 10.1523/JNEUROSCI.3865-14.2015 |
| PII | 35/14/5557 |
| PMID | 25855172 |
| PMC | PMC6605317 |
| MeSH | Animals Cell Adhesion Molecules / genetics Cells, Cultured Central Nervous System / cytology Conditioning, Classical / drug effects Conditioning, Classical / physiology* Cycloheximide / pharmacology Drosophila Drosophila Proteins / genetics Drosophila Proteins / metabolism* Eye Proteins / genetics Female Gene Expression Regulation / physiology* Homeodomain Proteins / metabolism* Hormone Antagonists / pharmacology Male Memory, Long-Term / drug effects Memory, Long-Term / physiology* Mice, Transgenic Mifepristone / pharmacology Mutation / genetics Neuroglia / drug effects Neuroglia / metabolism* Neurons / metabolism Protein Synthesis Inhibitors / pharmacology Proto-Oncogene Proteins c-myc / metabolism RNA Interference / physiology |
| IF | 6.074 |
| 引用数 | 13 |
| リソース情報 | |
| ショウジョウバエ | |