論文 - 詳細
| RRC ID | 57441 |
|---|---|
| 著者 | Takahashi KH. |
| タイトル | Little effect of HSP90 inhibition on the quantitative wing traits variation in Drosophila melanogaster. |
| ジャーナル | Genetica |
| Abstract |
Drosophila wings have been a model system to study the effect of HSP90 on quantitative trait variation. The effect of HSP90 inhibition on environmental buffering of wing morphology varies among studies while the genetic buffering effect of it was examined in only one study and was not detected. Variable results so far might show that the genetic background influences the environmental and genetic buffering effect of HSP90. In the previous studies, the number of the genetic backgrounds used is limited. To examine the effect of HSP90 inhibition with a larger number of genetic backgrounds than the previous studies, 20 wild-type strains of Drosophila melanogaster were used in this study. Here I investigated the effect of HSP90 inhibition on the environmental buffering of wing shape and size by assessing within-individual and among-individual variations, and as a result, I found little or very weak effects on environmental and genetic buffering. The current results suggest that the role of HSP90 as a global regulator of environmental and genetic buffering is limited at least in quantitative traits. |
| 巻・号 | 145(1) |
| ページ | 9-18 |
| 公開日 | 2017-2-1 |
| DOI | 10.1007/s10709-016-9940-z |
| PII | 10.1007/s10709-016-9940-z |
| PMID | 27909948 |
| MeSH | Animals Benzoquinones / pharmacology Drosophila melanogaster / drug effects Drosophila melanogaster / genetics* Female Genetic Variation* Genotype HSP90 Heat-Shock Proteins / antagonists & inhibitors* Inheritance Patterns / drug effects Lactams, Macrocyclic / pharmacology Male Phenotype Quantitative Trait, Heritable* Wings, Animal* / anatomy & histology |
| IF | 1.229 |
| 引用数 | 4 |
| リソース情報 | |
| ショウジョウバエ | |