| RRC ID |
57693
|
| Author |
Inoue R, Abdou K, Hayashi-Tanaka A, Muramatsu SI, Mino K, Inokuchi K, Mori H.
|
| Title |
Glucocorticoid receptor-mediated amygdalar metaplasticity underlies adaptive modulation of fear memory by stress.
|
| Journal |
Elife
|
| Abstract |
Glucocorticoid receptor (GR) is crucial for signaling mediated by stress-induced high levels of glucocorticoids. The lateral nucleus of the amygdala (LA) is a key structure underlying auditory-cued fear conditioning. Here, we demonstrate that genetic disruption of GR in the LA (LAGRKO) resulted in an auditory-cued fear memory deficit for strengthened conditioning. Furthermore, the suppressive effect of a single restraint stress (RS) prior to conditioning on auditory-cued fear memory in floxed GR (control) mice was abolished in LAGRKO mice. Optogenetic induction of long-term depression (LTD) at auditory inputs to the LA reduced auditory-cued fear memory in RS-exposed LAGRKO mice, and in contrast, optogenetic induction of long-term potentiation (LTP) increased auditory-cued fear memory in RS-exposed floxed GR mice. These findings suggest that prior stress suppresses fear conditioning-induced LTP at auditory inputs to the LA in a GR-dependent manner, thereby protecting animals from encoding excessive cued fear memory under stress conditions.
|
| Volume |
7
|
| Published |
2018-6-26
|
| DOI |
10.7554/eLife.34135
|
| PII |
34135
|
| PMID |
29941090
|
| PMC |
PMC6019067
|
| MeSH |
Acoustic Stimulation
Amygdala / anatomy & histology
Amygdala / physiology*
Animals
Conditioning, Psychological
Corticosterone / blood
Cues
Fear / physiology
Fear / psychology*
Immobilization
Integrases / genetics
Integrases / metabolism
Long-Term Potentiation / physiology
Male
Memory / physiology*
Mice
Mice, Inbred C57BL
Mice, Transgenic
Optogenetics / methods
Receptors, Glucocorticoid / deficiency
Receptors, Glucocorticoid / genetics*
Stress, Psychological / metabolism*
Stress, Psychological / physiopathology
Stress, Psychological / psychology
|
| IF |
7.08
|
| Times Cited |
2
|
| Resource |
| Mice |
RBRC01834 |
