論文 - 詳細
| RRC ID | 57693 |
|---|---|
| 著者 | Inoue R, Abdou K, Hayashi-Tanaka A, Muramatsu SI, Mino K, Inokuchi K, Mori H. |
| タイトル | Glucocorticoid receptor-mediated amygdalar metaplasticity underlies adaptive modulation of fear memory by stress. |
| ジャーナル | Elife |
| Abstract |
Glucocorticoid receptor (GR) is crucial for signaling mediated by stress-induced high levels of glucocorticoids. The lateral nucleus of the amygdala (LA) is a key structure underlying auditory-cued fear conditioning. Here, we demonstrate that genetic disruption of GR in the LA (LAGRKO) resulted in an auditory-cued fear memory deficit for strengthened conditioning. Furthermore, the suppressive effect of a single restraint stress (RS) prior to conditioning on auditory-cued fear memory in floxed GR (control) mice was abolished in LAGRKO mice. Optogenetic induction of long-term depression (LTD) at auditory inputs to the LA reduced auditory-cued fear memory in RS-exposed LAGRKO mice, and in contrast, optogenetic induction of long-term potentiation (LTP) increased auditory-cued fear memory in RS-exposed floxed GR mice. These findings suggest that prior stress suppresses fear conditioning-induced LTP at auditory inputs to the LA in a GR-dependent manner, thereby protecting animals from encoding excessive cued fear memory under stress conditions. |
| 巻・号 | 7 |
| 公開日 | 2018-6-26 |
| DOI | 10.7554/eLife.34135 |
| PII | 34135 |
| PMID | 29941090 |
| PMC | PMC6019067 |
| MeSH | Acoustic Stimulation Amygdala / anatomy & histology Amygdala / physiology* Animals Conditioning, Psychological Corticosterone / blood Cues Fear / physiology Fear / psychology* Immobilization Integrases / genetics Integrases / metabolism Long-Term Potentiation / physiology Male Memory / physiology* Mice Mice, Inbred C57BL Mice, Transgenic Optogenetics / methods Receptors, Glucocorticoid / deficiency Receptors, Glucocorticoid / genetics* Stress, Psychological / metabolism* Stress, Psychological / physiopathology Stress, Psychological / psychology |
| IF | 7.08 |
| 引用数 | 2 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 5 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 実験動物マウス | RBRC01834 |