論文 - 詳細
| RRC ID | 57757 |
|---|---|
| 著者 | Li M, Cui ZG, Zakki SA, Feng Q, Sun L, Feril LB Jr, Inadera H. |
| タイトル | Aluminum chloride causes 5-fluorouracil resistance in hepatocellular carcinoma HepG2 cells. |
| ジャーナル | J Cell Physiol |
| Abstract |
Chemoresistance is one of the major obstacles in chemotherapy-based hepatocellular carcinoma (HCC) intervention. Aluminum (Al) is an environmental pollutant that plays a vital role in carcinogenesis, tumorigenesis, and metastasis. However, the effect of Al on chemoresistance remains unknown. 5-Fluorouracil (5-FU) is a widely used antitumor drug. Therefore, we investigated the effects of aluminum chloride (AlCl3 ) on the chemoresistance of HepG2 cells to 5-FU and explored the underlying mechanisms of these effects. The results demonstrated that AlCl3 pretreatment attenuated 5-FU-induced apoptosis through Erk activation and reversed 5-FU-induced cell cycle arrest by downregulating p-Chk2Thr68 levels. In addition, AlCl3 markedly increased the levels of proteins associated with cell migration, such as MMP-2 and MMP-9. Further investigation demonstrated that an Erk inhibitor (U0126) reversed the AlCl3 -induced decrease in apoptosis, enhancement of cell cycle progression, promotion of cell migration, and attenuation of oxidative stress. In summary, AlCl3 induced chemoresistance to 5-FU in HepG2 cells. The present study suggests a potential influence of AlCl3 on 5-FU therapy. These findings may help others to understand and properly address the resistance of HCC to chemotherapeutic agents. |
| 巻・号 | 234(11) |
| ページ | 20249-20265 |
| 公開日 | 2019-11-1 |
| DOI | 10.1002/jcp.28625 |
| PMID | 30993729 |
| MeSH | Aluminum Chloride / pharmacology* Apoptosis / drug effects Carcinoma, Hepatocellular / drug therapy* Cell Cycle Checkpoints / drug effects Cell Line, Tumor Cell Movement / drug effects Cell Proliferation / drug effects Down-Regulation / drug effects Drug Resistance, Neoplasm / drug effects* Fluorouracil / pharmacology* Gene Expression Regulation, Neoplastic / drug effects Hep G2 Cells Humans Liver Neoplasms / drug therapy* Oxidative Stress / drug effects Signal Transduction / drug effects |
| IF | 4.522 |
| 引用数 | 1 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 各媒体での言及数の合計 | 0 |
| リソース情報 | |
| ヒト・動物細胞 | Hep G2(RCB1886) |