論文 - 詳細
| RRC ID | 57782 |
|---|---|
| 著者 | Prakash V, Carson BB, Feenstra JM, Dass RA, Sekyrova P, Hoshino A, Petersen J, Guo Y, Parks MM, Kurylo CM, Batchelder JE, Haller K, Hashimoto A, Rundqivst H, Condeelis JS, Allis CD, Drygin D, Nieto MA, Andäng M, Percipalle P, Bergh J, Adameyko I, Farrants AÖ, Hartman J, Lyden D, Pietras K, Blanchard SC, Vincent CT. |
| タイトル | Ribosome biogenesis during cell cycle arrest fuels EMT in development and disease. |
| ジャーナル | Nat Commun |
| Abstract |
Ribosome biogenesis is a canonical hallmark of cell growth and proliferation. Here we show that execution of Epithelial-to-Mesenchymal Transition (EMT), a migratory cellular program associated with development and tumor metastasis, is fueled by upregulation of ribosome biogenesis during G1/S arrest. This unexpected EMT feature is independent of species and initiating signal, and is accompanied by release of the repressive nucleolar chromatin remodeling complex (NoRC) from rDNA, together with recruitment of the EMT-driving transcription factor Snai1 (Snail1), RNA Polymerase I (Pol I) and the Upstream Binding Factor (UBF). EMT-associated ribosome biogenesis is also coincident with increased nucleolar recruitment of Rictor, an essential component of the EMT-promoting mammalian target of rapamycin complex 2 (mTORC2). Inhibition of rRNA synthesis in vivo differentiates primary tumors to a benign, Estrogen Receptor-alpha (ERα) positive, Rictor-negative phenotype and reduces metastasis. These findings implicate the EMT-associated ribosome biogenesis program with cellular plasticity, de-differentiation, cancer progression and metastatic disease. |
| 巻・号 | 10(1) |
| ページ | 2110 |
| 公開日 | 2019-5-8 |
| DOI | 10.1038/s41467-019-10100-8 |
| PII | 10.1038/s41467-019-10100-8 |
| PMID | 31068593 |
| PMC | PMC6506521 |
| MeSH | Animals Breast Neoplasms / genetics Breast Neoplasms / pathology Cell Differentiation / physiology Cell Line, Tumor / transplantation Cell Movement / physiology Cell Nucleolus / metabolism Chick Embryo Chromosomal Proteins, Non-Histone / metabolism DNA, Ribosomal / metabolism Disease Models, Animal Epithelial-Mesenchymal Transition / physiology* Female G1 Phase Cell Cycle Checkpoints / physiology* Gene Expression Profiling Gene Expression Regulation, Developmental* Gene Expression Regulation, Neoplastic* Humans Mice Mice, Inbred C57BL Mice, Transgenic RNA, Ribosomal / metabolism Ribosomes / genetics Ribosomes / metabolism* |
| IF | 12.121 |
| 引用数 | 16 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 53 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | NMuMG/Fucci2(RCB2868) |