論文 - 詳細
| RRC ID | 57816 |
|---|---|
| 著者 | Teramoto K, Katoh H. |
| タイトル | The cystine/glutamate antiporter xCT is a key regulator of EphA2 S897 phosphorylation under glucose-limited conditions. |
| ジャーナル | Cell Signal |
| Abstract |
EphA2, which belongs to the Eph family of receptor tyrosine kinases, is overexpressed in a variety of human cancers. Serine 897 (S897) phosphorylation of EphA2 is known to promote cancer cell migration and proliferation in a ligand-independent manner. In this study, we show that glucose deprivation induces S897 phosphorylation of EphA2 in glioblastoma cells. The phosphorylation requires the activity of the cystine/glutamate antiporter xCT and reactive oxygen species (ROS)-dependent ERK and RSK activation. Furthermore, depletion of EphA2 in glioblastoma cells leads to decreased cell viability under glucose starvation. Our results suggest a role of EphA2 in glioblastoma cell viability under glucose-limited conditions. |
| 巻・号 | 62 |
| ページ | 109329 |
| 公開日 | 2019-10-1 |
| DOI | 10.1016/j.cellsig.2019.05.014 |
| PII | S0898-6568(19)30119-6 |
| PMID | 31152846 |
| MeSH | Amino Acid Transport System y+ / genetics* Antiporters / genetics* Cell Line, Tumor Cell Movement / genetics Cell Survival / genetics Cystine / metabolism Gene Expression Regulation, Neoplastic / genetics Glioblastoma Glucose / metabolism* Glutamic Acid / genetics Glutamic Acid / metabolism Humans MAP Kinase Signaling System / genetics Phosphorylation / genetics Reactive Oxygen Species / metabolism Receptor, EphA2 / genetics* Serine / metabolism |
| IF | 3.968 |
| 引用数 | 1 |
| リソース情報 | |
| ヒト・動物細胞 | A172(RCB2530) |