RRC ID 58212
著者 Watanabe K, Kanaoka Y, Mizutani S, Uchiyama H, Yajima S, Watada M, Uemura T, Hattori Y.
タイトル Interspecies Comparative Analyses Reveal Distinct Carbohydrate-Responsive Systems among Drosophila Species.
ジャーナル Cell Rep
Abstract During evolution, organisms have acquired variable feeding habits. Some species are nutritional generalists that adapt to various food resources, while others are specialists, feeding on specific resources. However, much remains to be discovered about how generalists adapt to diversified diets. We find that larvae of the generalists Drosophila melanogaster and D. simulans develop on three diets with different nutrient balances, whereas specialists D. sechellia and D. elegans cannot develop on carbohydrate-rich diets. The generalist D. melanogaster downregulates the expression of diverse metabolic genes systemically by transforming growth factor β (TGF-β)/Activin signaling, maintains metabolic homeostasis, and successfully adapts to the diets. In contrast, the specialist D. sechellia expresses those metabolic genes at higher levels and accumulates various metabolites on the carbohydrate-rich diet, culminating in reduced adaptation. Phenotypic similarities and differences strongly suggest that the robust carbohydrate-responsive regulatory systems are evolutionarily retained through genome-environment interactions in the generalists and contribute to their nutritional adaptabilities.
巻・号 28(10)
ページ 2594-2607.e7
公開日 2019-9-3
DOI 10.1016/j.celrep.2019.08.030
PII S2211-1247(19)31064-2
PMID 31484071
MeSH Adaptation, Physiological / genetics Animals Carbohydrate Metabolism* / genetics Diet Drosophila / genetics Drosophila / metabolism* Food Gene Expression Regulation Metabolome Mutation / genetics Species Specificity
IF 8.109
引用数 3
リソース情報
ショウジョウバエ E-10002 HK0461.03 K-S05 K-S10 K-S02