論文 - 詳細
| RRC ID | 5838 |
|---|---|
| 著者 | Herpin A, Nakamura S, Wagner TU, Tanaka M, Schartl M. |
| タイトル | A highly conserved cis-regulatory motif directs differential gonadal synexpression of Dmrt1 transcripts during gonad development. |
| ジャーナル | Nucleic Acids Res |
| Abstract |
Differential gene expression largely accounts for the coordinated manifestation of the genetic programme underlying embryonic development and cell differentiation. The 3' untranslated region (3'-UTR) of eukaryotic genes can contain motifs involved in regulation of gene expression at the post-transcriptional level. In the 3'-UTR of dmrt1, a key gene that functions in gonad development and differentiation, an 11-bp protein-binding motif was identified that mediates gonad-specific mRNA localization during embryonic and larval development of fish. Mutations that disrupt the 11-bp motif leading to in vitro protein-binding loss and selective transcript stabilization failure indicate a role for this motif in RNA stabilization through protein binding. The sequence motif was found to be conserved in most of the dmrt1 homologous genes from flies to humans suggesting a widespread conservation of this specific mechanism. |
| 巻・号 | 37(5) |
| ページ | 1510-20 |
| 公開日 | 2009-4-1 |
| DOI | 10.1093/nar/gkn1065 |
| PII | gkn1065 |
| PMID | 19139075 |
| PMC | PMC2655695 |
| MeSH | 3' Untranslated Regions / chemistry* Animals Cells, Cultured Fish Proteins / biosynthesis Fish Proteins / genetics* Gene Expression Regulation, Developmental* Gonads / embryology Gonads / growth & development Gonads / metabolism* Humans Mesoderm / metabolism Oryzias / embryology Oryzias / genetics Oryzias / growth & development Protein Biosynthesis RNA Stability RNA, Messenger / metabolism RNA-Binding Proteins / metabolism Regulatory Sequences, Ribonucleic Acid* Transcription Factors / biosynthesis Transcription Factors / genetics* |
| IF | 11.502 |
| 引用数 | 13 |
| WOS 分野 | BIOCHEMISTRY & MOLECULAR BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 各媒体での言及数の合計 | 0 |
| リソース情報 | |
| メダカ | Carbio strain (Cab) |