論文 - 詳細
| RRC ID | 58658 |
|---|---|
| 著者 | Ren T, Fan XX, Wang MF, Duan FG, Wei CL, Li RZ, Jiang ZB, Wang YW, Yao XJ, Chen MW, Tang YJ, Leung EL. |
| タイトル | miR‑20b promotes growth of non‑small cell lung cancer through a positive feedback loop of the Wnt/β‑catenin signaling pathway. |
| ジャーナル | Int J Oncol |
| Abstract |
microRNAs (miRNAs or miRs) are endogenous noncoding single‑stranded RNA molecules that can regulate gene expression by targeting the 3'‑untranslated region and play an important role in many biological and pathological processes, such as inflammation and cancer. In this study, we found that miR‑20b was significantly increased in human non‑small cell lung cancer (NSCLC) cell lines and patient tissues, suggesting that it may possess a carcinogenic role in lung cancer. This miRNA promoted the proliferation, migration and invasion of NSCLC cells by targeting and downregulating the expression of adenomatous polyposis coli (APC), which is a negative regulator of the canonical Wnt signaling pathway. Wnt signaling activation may increase transcription of miR‑20b. Therefore, miR‑20b and canonical Wnt signaling were coupled through a feed‑forward positive feedback loop, forming a biological regulatory circuit. Finally, an in vivo investigation further demonstrated that an increase in miR‑20b promoted the growth of cancer cells. Overall, our findings offer evidence that miR‑20b may contribute to the development of NSCLC by inhibiting APC via the canonical Wnt signaling pathway. |
| 巻・号 | 56(2) |
| ページ | 470-479 |
| 公開日 | 2020-2-1 |
| DOI | 10.3892/ijo.2019.4940 |
| PMID | 31894264 |
| PMC | PMC6959373 |
| MeSH | Adenomatous Polyposis Coli Protein / genetics* Aged Animals Carcinoma, Non-Small-Cell Lung / blood Carcinoma, Non-Small-Cell Lung / genetics* Carcinoma, Non-Small-Cell Lung / pathology Carcinoma, Non-Small-Cell Lung / surgery Case-Control Studies Cell Line, Tumor Cell Movement / genetics Cell Proliferation / genetics Feedback, Physiological Female Gene Expression Regulation, Neoplastic Healthy Volunteers Humans Lung / pathology Lung / surgery Lung Neoplasms / blood Lung Neoplasms / genetics* Lung Neoplasms / pathology Lung Neoplasms / surgery Male Mice MicroRNAs / metabolism* Middle Aged Neoplasm Invasiveness / genetics Pneumonectomy Wnt Signaling Pathway / genetics* Xenograft Model Antitumor Assays |
| IF | 3.899 |
| 引用数 | 0 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | PC-9(RCB4455) |