Reference - Detail
| RRC ID | 58737 |
|---|---|
| Author | Momoi Y, Nishikimi A, Du G, Kataoka T, Katagiri K. |
| Title | Phosphatidic acid regulates subcellular distribution of RA-GEFs critical for chemokine-dependent migration. |
| Journal | Biochem Biophys Res Commun |
| Abstract |
Integrin activation by Rap1-GTP is pivotal for lymphocyte trafficking. In this study, we show the phosphatidic acid (PA)-dependent membrane distribution of RA-GEF-1 and -2 (also known as Rapgef2 and 6), which are guanine nucleotide exchange factors for Rap1, plays important roles in lymphocyte migration. RA-GEF-1 associates with PA through 919-967 aa within CDC25 homology domain, and the deletion of this region of RA-GEF-1 inhibits chemokine-dependent migration. Chemokine stimulation induces temporal production of PA on the plasma membrane, which is not necessary for Rap1 activation, but the translocation of RA-GEFs. Thus, chemokine-dependent generation of PA is critical for lymphocyte migration through membrane localization of RA-GEFs. |
| Volume | 524(2) |
| Pages | 325-331 |
| Published | 2020-4-2 |
| DOI | 10.1016/j.bbrc.2020.01.080 |
| PII | S0006-291X(20)30149-2 |
| PMID | 31996307 |
| MeSH | Animals Cell Line Cell Movement* Chemokines / metabolism* Guanine Nucleotide Exchange Factors / metabolism* HEK293 Cells Humans Lymphocytes / cytology Lymphocytes / metabolism Mice Phosphatidic Acids / metabolism* |
| IF | 2.985 |
| Times Cited | 1 |
| Altmetric score |
オルトメトリクス指標項目
|
| The most frequently cited source | X(Twitter) |
| Total number of mentions | 1 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Human and Animal Cells | 293T(RCB2202) |