| RRC ID |
58771
|
| 著者 |
Wu G, Yang Z, Chen Y, Li X, Yang J, Yin T.
|
| タイトル |
Downregulation of Lnc-OC1 attenuates the pathogenesis of polycystic ovary syndrome.
|
| ジャーナル |
Mol Cell Endocrinol
|
| Abstract |
Long non-coding RNAs (lncRNAs) play a vital role in the progression of many human diseases. The aim of this study is to explore the relationship between lncRNA-ovarian cancer associated 1 (Lnc-OC1) and PCOS. In this study, we found that Lnc-OC1 was significantly higher in PCOS granulosa cells (GCs) compared to non-PCOS GCs. Lnc-OC1 knockdown inhibited cell viability and promoted cell apoptosis, expression of aromatase mRNA and production of estradiol in KGN cells. In PCOS mice, Lnc-OC1 promoted the serum insulin release, production of angiogenesis-related factors and IκBα phosphorylation, which could be partially restored by Lnc-OC1 shRNA. These results suggest that Lnc-OC1 plays an important part in the pathogenesis of PCOS.
|
| 巻・号 |
506
|
| ページ |
110760
|
| 公開日 |
2020-4-15
|
| DOI |
10.1016/j.mce.2020.110760
|
| PII |
S0303-7207(20)30060-5
|
| PMID |
32070768
|
| MeSH |
Adult
Animals
Case-Control Studies
Cell Survival / drug effects
Cell Survival / genetics
Cells, Cultured
Down-Regulation / drug effects
Down-Regulation / genetics
Female
Gene Knockdown Techniques
Granulosa Cells / drug effects
Granulosa Cells / metabolism
Granulosa Cells / pathology
Humans
Mice
Mice, Inbred C57BL
Polycystic Ovary Syndrome / genetics*
Polycystic Ovary Syndrome / pathology
RNA, Long Noncoding / antagonists & inhibitors
RNA, Long Noncoding / genetics*
RNA, Small Interfering / pharmacology
Young Adult
|
| IF |
3.871
|
| 引用数 |
0
|
| リソース情報 |
| ヒト・動物細胞 |
KGN(RCB1154) |
