Reference - Detail
RRC ID | 58780 |
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Author | Yamada Y, Fukuda Y, Sasaki D, Maruyama M, Harashima H. |
Title | Development of a nanoparticle that releases nucleic acids in response to a mitochondrial environment. |
Journal | Mitochondrion |
Abstract |
The delivery of nucleic acids targeting mutant mtDNA represent a potential strategy for addressing a variety of mitochondria-related diseases. We previously developed a MITO-Porter, a nano carrier that is capable of delivering nanoparticles of nucleic acids to mitochondria of human cells. Here, we report on an investigation of a series of nanoparticles formed with various poly cationic peptides that can release nucleic acids in response to a mitochondrial environment. A significant relationship was found between the number of and the location of arginine and histidine residues in the peptide sequence and the release of nucleic acids in a mitochondrial environment. |
Volume | 52 |
Pages | 67-74 |
Published | 2020-5-1 |
DOI | 10.1016/j.mito.2020.02.009 |
PII | S1567-7249(19)30225-9 |
PMID | 32097722 |
MeSH | Amino Acid Sequence Arginine / chemistry Cell Line DNA, Mitochondrial / drug effects* DNA, Mitochondrial / genetics Histidine / chemistry Humans Membrane Potential, Mitochondrial / drug effects Mitochondria / drug effects Mitochondria / genetics* Mutation Nanoparticles Peptides / chemistry* RNA / chemistry RNA / pharmacology* |
IF | 3.992 |
Times Cited | 0 |
Resource | |
Human and Animal Cells | NB1RGB(RCB0222) |