論文 - 詳細
RRC ID | 58780 |
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著者 | Yamada Y, Fukuda Y, Sasaki D, Maruyama M, Harashima H. |
タイトル | Development of a nanoparticle that releases nucleic acids in response to a mitochondrial environment. |
ジャーナル | Mitochondrion |
Abstract |
The delivery of nucleic acids targeting mutant mtDNA represent a potential strategy for addressing a variety of mitochondria-related diseases. We previously developed a MITO-Porter, a nano carrier that is capable of delivering nanoparticles of nucleic acids to mitochondria of human cells. Here, we report on an investigation of a series of nanoparticles formed with various poly cationic peptides that can release nucleic acids in response to a mitochondrial environment. A significant relationship was found between the number of and the location of arginine and histidine residues in the peptide sequence and the release of nucleic acids in a mitochondrial environment. |
巻・号 | 52 |
ページ | 67-74 |
公開日 | 2020-5-1 |
DOI | 10.1016/j.mito.2020.02.009 |
PII | S1567-7249(19)30225-9 |
PMID | 32097722 |
MeSH | Amino Acid Sequence Arginine / chemistry Cell Line DNA, Mitochondrial / drug effects* DNA, Mitochondrial / genetics Histidine / chemistry Humans Membrane Potential, Mitochondrial / drug effects Mitochondria / drug effects Mitochondria / genetics* Mutation Nanoparticles Peptides / chemistry* RNA / chemistry RNA / pharmacology* |
IF | 3.992 |
引用数 | 0 |
リソース情報 | |
ヒト・動物細胞 | NB1RGB(RCB0222) |