| RRC ID |
58794
|
| Author |
Haruna M, Hirata M, Iwahori K, Kanazawa T, Yamamoto Y, Goto K, Kawashima A, Morimoto-Okazawa A, Funaki S, Shintani Y, Kumanogoh A, Wada H.
|
| Title |
Docetaxel Upregulates HMGB1 Levels in Non-small Cell Lung Cancer.
|
| Journal |
Biol Pharm Bull
|
| Abstract |
Immune checkpoint inhibitors (ICIs) exert beneficial effects in non-small cell lung cancer (NSCLC) patients. However, ICIs are only advantageous for a limited population of NSCLC patients. Therefore to enhance their effects, combination therapies with ICIs have been developed. To identify preferable chemotherapy to combine with ICIs against lung cancer, we examined immunological effects of docetaxel compared with epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI). We found no difference in peripheral lymphocyte counts and ratio of their subpopulations in lung cancer patients before and after both treatments. On the other hand, plasma levels of high-mobility group box 1 (HMGB1), a damage-associated molecular pattern (DAMP) protein, showed significant increase after docetaxel treatment. Furthermore, we investigated effects of HMGB1 on tumor-infiltrating immune cells obtained from surgically resected tumor tissue from NSCLC patients. When the tumor infiltrating cells were stimulated with HMGB1, CD11c+ cells showed increased expression of activation markers. These findings imply that docetaxel could be involved in anti-tumor immunity via HMGB1. Therefore docetaxel might be a candidate for combination treatment with ICIs.
|
| Volume |
43(3)
|
| Pages |
399-403
|
| Published |
2020-1-1
|
| DOI |
10.1248/bpb.b19-00702
|
| PMID |
32115500
|
| MeSH |
A549 Cells
Antineoplastic Agents
CD11 Antigens / metabolism
Carcinoma, Non-Small-Cell Lung / drug therapy*
Cell Line, Tumor
Chemokines / metabolism
Combined Modality Therapy
Cytokines / metabolism
Docetaxel / pharmacology*
Epidermal Growth Factor / antagonists & inhibitors*
ErbB Receptors / antagonists & inhibitors*
Female
HMGB1 Protein / blood
HMGB1 Protein / metabolism*
Humans
Integrin alpha Chains / metabolism
Male
Mutation
Protein Kinase Inhibitors / pharmacology*
Protein-Tyrosine Kinases / antagonists & inhibitors
Transcriptional Activation / drug effects
|
| IF |
1.863
|
| Times Cited |
0
|
| Resource |
| Human and Animal Cells |
RERF-LC-AI(RCB0444)
EBC-1(RCB1965) |
