論文 - 詳細
| RRC ID | 59035 |
|---|---|
| 著者 | Shohayeb B, Mitchell N, Millard SS, Quinn LM, Ng DCH. |
| タイトル | Elevated levels of Drosophila Wdr62 promote glial cell growth and proliferation through AURKA signalling to AKT and MYC. |
| ジャーナル | Biochim Biophys Acta Mol Cell Res |
| Abstract |
WD40-Repeat Protein 62 (WDR62) is required to maintain neural and glial cell populations during embryonic brain growth. Although elevated expression of WDR62 is frequently associated with several tumour types, potential effects of excess WDR62 on proliferative growth remain undefined. Here, we demonstrate that glia specific overexpression of WDR62 in Drosophila larval brains resulted in increased cell size, over-proliferation and increased brain volume, without overt disruption of tissue organization. We further demonstrate WDR62 promoted over-proliferation and brain overgrowth by activating AURKA and pAKT signalling to increase MYC function in glial cells. Together these data suggest WDR62 normally functions in the glial lineage to activate oncogenic signalling networks, promoting proliferation and brain overgrowth. |
| 巻・号 | 1867(7) |
| ページ | 118713 |
| 公開日 | 2020-7-1 |
| DOI | 10.1016/j.bbamcr.2020.118713 |
| PII | S0167-4889(20)30071-9 |
| PMID | 32246948 |
| MeSH | Animals Aurora Kinase A / genetics* Brain / growth & development Brain / metabolism Cell Proliferation / genetics DNA-Binding Proteins / genetics* Drosophila / genetics Drosophila / growth & development Drosophila Proteins / genetics* Nerve Tissue Proteins / genetics* Neurogenesis / genetics Neuroglia / metabolism Proto-Oncogene Proteins c-akt / genetics Signal Transduction / genetics Spindle Apparatus / genetics Transcription Factors / genetics* |
| IF | 4.739 |
| 引用数 | 0 |
| リソース情報 | |
| ショウジョウバエ | 7337-R1 |