RRC ID 59037
Author Matsushita R, Nishimura T.
Title Trehalose metabolism confers developmental robustness and stability in Drosophila by regulating glucose homeostasis.
Journal Commun Biol
Abstract Organisms have evolved molecular mechanisms to ensure consistent and invariant phenotypes in the face of environmental fluctuations. Developmental homeostasis is determined by two factors: robustness, which buffers against environmental variations; and developmental stability, which buffers against intrinsic random variations. However, our understanding of these noise-buffering mechanisms remains incomplete. Here, we showed that appropriate glycemic control confers developmental homeostasis in the fruit fly Drosophila. We found that circulating glucose levels are buffered by trehalose metabolism, which acts as a glucose sink in circulation. Furthermore, mutations in trehalose synthesis enzyme (Tps1) increased the among-individual and within-individual variations in wing size. Whereas wild-type flies were largely resistant to changes in dietary carbohydrate and protein levels, Tps1 mutants experienced significant disruptions in developmental homeostasis in response to dietary stress. These results demonstrate that glucose homeostasis against dietary stress is crucial for developmental homeostasis.
Volume 3(1)
Pages 170
Published 2020-4-7
DOI 10.1038/s42003-020-0889-1
PII 10.1038/s42003-020-0889-1
PMID 32265497
PMC PMC7138798
MeSH Animal Nutritional Physiological Phenomena Animals Blood Glucose / metabolism* Dietary Carbohydrates / metabolism Drosophila Proteins / genetics Drosophila Proteins / metabolism Drosophila melanogaster / genetics Drosophila melanogaster / metabolism* Female Genotype Glucosyltransferases / genetics Glucosyltransferases / metabolism Homeostasis Male Mutation Nutritional Status Phenotype Stress, Physiological* Trehalose / metabolism*
IF 4.165
Times Cited 0
Drosophila 4104R-6 9364R-1