論文 - 詳細
| RRC ID | 59037 |
|---|---|
| 著者 | Matsushita R, Nishimura T. |
| タイトル | Trehalose metabolism confers developmental robustness and stability in Drosophila by regulating glucose homeostasis. |
| ジャーナル | Commun Biol |
| Abstract |
Organisms have evolved molecular mechanisms to ensure consistent and invariant phenotypes in the face of environmental fluctuations. Developmental homeostasis is determined by two factors: robustness, which buffers against environmental variations; and developmental stability, which buffers against intrinsic random variations. However, our understanding of these noise-buffering mechanisms remains incomplete. Here, we showed that appropriate glycemic control confers developmental homeostasis in the fruit fly Drosophila. We found that circulating glucose levels are buffered by trehalose metabolism, which acts as a glucose sink in circulation. Furthermore, mutations in trehalose synthesis enzyme (Tps1) increased the among-individual and within-individual variations in wing size. Whereas wild-type flies were largely resistant to changes in dietary carbohydrate and protein levels, Tps1 mutants experienced significant disruptions in developmental homeostasis in response to dietary stress. These results demonstrate that glucose homeostasis against dietary stress is crucial for developmental homeostasis. |
| 巻・号 | 3(1) |
| ページ | 170 |
| 公開日 | 2020-4-7 |
| DOI | 10.1038/s42003-020-0889-1 |
| PII | 10.1038/s42003-020-0889-1 |
| PMID | 32265497 |
| PMC | PMC7138798 |
| MeSH | Animal Nutritional Physiological Phenomena Animals Blood Glucose / metabolism* Dietary Carbohydrates / metabolism Drosophila Proteins / genetics Drosophila Proteins / metabolism Drosophila melanogaster / genetics Drosophila melanogaster / metabolism* Female Genotype Glucosyltransferases / genetics Glucosyltransferases / metabolism Homeostasis Male Mutation Nutritional Status Phenotype Stress, Physiological* Trehalose / metabolism* |
| IF | 4.165 |
| 引用数 | 0 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 7 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | 4104R-6 9364R-1 |