論文 - 詳細
| RRC ID | 59125 |
|---|---|
| 著者 | Slaidina M, Banisch TU, Gupta S, Lehmann R. |
| タイトル | A single-cell atlas of the developing Drosophila ovary identifies follicle stem cell progenitors. |
| ジャーナル | Genes Dev |
| Abstract |
Addressing the complexity of organogenesis at a system-wide level requires a complete understanding of adult cell types, their origin, and precursor relationships. The Drosophila ovary has been a model to study how coordinated stem cell units, germline, and somatic follicle stem cells maintain and renew an organ. However, lack of cell type-specific tools have limited our ability to study the origin of individual cell types and stem cell units. Here, we used a single-cell RNA sequencing approach to uncover all known cell types of the developing ovary, reveal transcriptional signatures, and identify cell type-specific markers for lineage tracing. Our study identifies a novel cell type corresponding to the elusive follicle stem cell precursors and predicts subtypes of known cell types. Altogether, we reveal a previously unanticipated complexity of the developing ovary and provide a comprehensive resource for the systematic analysis of ovary morphogenesis. |
| 巻・号 | 34(3-4) |
| ページ | 239-249 |
| 公開日 | 2020-2-1 |
| DOI | 10.1101/gad.330464.119 |
| PII | gad.330464.119 |
| PMID | 31919193 |
| PMC | PMC7000915 |
| MeSH | Animals Drosophila / cytology* Drosophila / genetics Drosophila / metabolism Female Models, Animal Ovarian Follicle / cytology* Ovary / cytology Sequence Analysis, RNA Single-Cell Analysis Stem Cells / cytology* Transcription, Genetic |
| IF | 9.527 |
| 引用数 | 1 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 15 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | DGRC#108066 |