論文 - 詳細
| RRC ID | 5913 |
|---|---|
| 著者 | Yasunaga K, Kanamori T, Morikawa R, Suzuki E, Emoto K. |
| タイトル | Dendrite reshaping of adult Drosophila sensory neurons requires matrix metalloproteinase-mediated modification of the basement membranes. |
| ジャーナル | Dev Cell |
| Abstract |
In response to changes in the environment, dendrites from certain neurons change their shape, yet the mechanism remains largely unknown. Here we show that dendritic arbors of adult Drosophila sensory neurons are rapidly reshaped from a radial shape to a lattice-like shape within 24 hr after eclosion. This radial-to-lattice reshaping arises from rearrangement of the existing radial branches into the lattice-like pattern, rather than extensive dendrite pruning followed by regrowth of the lattice-shaped arbors over the period. We also find that the dendrite reshaping is completely blocked in mutants for the matrix metalloproteinase (Mmp) 2. Further genetic analysis indicates that Mmp2 promotes the dendrite reshaping through local degradation of the basement membrane upon which dendrites of the sensory neurons innervate. These findings suggest that regulated proteolytic alteration of the extracellular matrix microenvironment might be a fundamental mechanism to drive a large-scale change of dendritic structures during reorganization of neuronal circuits. |
| 巻・号 | 18(4) |
| ページ | 621-32 |
| 公開日 | 2010-4-20 |
| DOI | 10.1016/j.devcel.2010.02.010 |
| PII | S1534-5807(10)00108-5 |
| PMID | 20412776 |
| MeSH | Animals Basement Membrane / enzymology* Dendrites / metabolism Drosophila melanogaster / metabolism* Epithelial Cells / enzymology Extracellular Matrix / metabolism Female Gene Expression Regulation, Enzymologic* Male Matrix Metalloproteinases / metabolism* Models, Biological Models, Genetic Muscles / enzymology Neurons / metabolism* Time Factors |
| IF | 10.092 |
| 引用数 | 36 |
| WOS 分野 | DEVELOPMENTAL BIOLOGY CELL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | F1000Research |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | NP0509 (DGRC#103625) |