RRC ID 59138
Author Senapati B, Tsao CH, Juan YA, Chiu TH, Wu CL, Waddell S, Lin S.
Title A neural mechanism for deprivation state-specific expression of relevant memories in Drosophila.
Journal Nat Neurosci
Abstract Motivational states modulate how animals value sensory stimuli and engage in goal-directed behaviors. The motivational states of thirst and hunger are represented in the brain by shared and unique neuromodulatory systems. However, it is unclear how such systems interact to coordinate the expression of appropriate state-specific behavior. We show that the activity of two brain neurons expressing leucokinin neuropeptide is elevated in thirsty and hungry flies, and that leucokinin release is necessary for state-dependent expression of water- and sugar-seeking memories. Leucokinin inhibits two types of mushroom-body-innervating dopaminergic neurons (DANs) to promote thirst-specific water memory expression, whereas it activates other mushroom-body-innervating DANs to facilitate hunger-dependent sugar memory expression. Selection of hunger- or thirst-appropriate memory emerges from competition between leucokinin and other neuromodulatory hunger signals at the level of the DANs. Therefore, coordinated modulation of the dopaminergic system allows flies to prioritize the expression of the relevant state-dependent motivated behavior.
Volume 22(12)
Pages 2029-2039
Published 2019-12-1
DOI 10.1038/s41593-019-0515-z
PII 10.1038/s41593-019-0515-z
PMID 31659341
PMC PMC6885014
MeSH Animals Animals, Inbred Strains Behavior, Animal / physiology Cues Dopaminergic Neurons / physiology* Drosophila* Female Food Deprivation / physiology Hunger / physiology* Male Memory / physiology* Mushroom Bodies / physiology Neural Inhibition / physiology Neurons / metabolism Neuropeptides / metabolism Neuropeptides / physiology* Thirst / physiology* Water Water Deprivation / physiology
IF 20.071
Times Cited 1
Drosophila DGRC#108846