RRC ID 59182
著者 Kidera H, Hatabu T, Takahashi KH.
タイトル Apoptosis inhibition mitigates aging effects in Drosophila melanogaster.
ジャーナル Genetica
Abstract Aging is a natural biological process that results in progressive loss of cell, tissue, and organ function. One of the causing factors of the aging process is the decrease in muscle mass, which has not been fully verified in Drosophila. Apoptotic cell death may result in aberrant cell loss and can eventually diminish tissue function and muscle atrophy. If so, inhibition of apoptosis may prolong longevity and reduce motor function and muscle mass decline with age in Drosophila flies. Here, we used Drosophila melanogaster as study material, and induced the overexpression of Drosophila inhibitor of apoptosis protein 1 gene to inhibit apoptosis, and investigated the effect of apoptosis inhibition on the longevity and age-related declines in flight and climbing ability and muscle mass. As a result, the inhibition of apoptosis tended to mitigate the aging effects and prolonged longevity and reduced climbing ability decline with age. The current study suggests that apoptosis inhibition could mitigate the aging effects in D. melanogaster. Although such effects have already been known in mammals, the current results suggest that the apoptosis may play a similar role in insects as well.
巻・号 148(2)
ページ 69-76
公開日 2020-4-1
DOI 10.1007/s10709-020-00088-1
PII 10.1007/s10709-020-00088-1
PMID 32219590
MeSH Aging / genetics* Animals Apoptosis / genetics Drosophila Proteins / genetics* Drosophila melanogaster / genetics Drosophila melanogaster / growth & development Longevity / genetics* Male Muscle, Skeletal / growth & development Muscle, Skeletal / metabolism Muscle, Skeletal / pathology Muscular Atrophy / genetics Muscular Atrophy / physiopathology
IF 1.186
引用数 0
リソース情報
ショウジョウバエ DGRC#108069