RRC ID 59222
Author Sakae Y, Oikawa A, Sugiura Y, Mita M, Nakamura S, Nishimura T, Suematsu M, Tanaka M.
Title Starvation causes female-to-male sex reversal through lipid metabolism in the teleost fish, medaka (Olyzias latipes).
Journal Biol Open
Abstract The teleost fish, medaka (Oryzias latipes), employs the XX/XY genetic sex determination system. We show here that the phenotypic sex of medaka is affected by changes in lipid metabolism. Medaka larvae subjected to 5 days of starvation underwent female-to-male sex reversal. Metabolomic and RT-qPCR analyses indicated that pantothenate metabolism was suppressed by starvation. Consistently, inhibiting the pantothenate metabolic pathway caused sex reversal. The final metabolite in this pathway is coenzyme A, an essential factor for lipogenesis. Inhibiting fatty acid synthesis, the first step of lipogenesis, also caused sex reversal. The expression of dmrt1, a critical gene for male development, was suppressed by starvation, and a dmrt1 (Δ13) mutant did not show sex reversal under starvation. Collectively, these results indicate that fatty acid synthesis is involved in female-to-male sex reversal through ectopic expression of male gene dmrt1 under starvation.
Volume 9(4)
Published 2020-4-7
DOI 10.1242/bio.050054
PII 9/4/bio050054
PMID 32265199
PMC PMC7132775
IF 2.029
Times Cited 0
Medaka OK-Cab (MT830) d-rR/TOKYO (MT837)