論文 - 詳細
| RRC ID | 59341 |
|---|---|
| 著者 | Fan L, Kovacevic I, Heiman MG, Bao Z. |
| タイトル | A multicellular rosette-mediated collective dendrite extension. |
| ジャーナル | Elife |
| Abstract |
Coordination of neurite morphogenesis with surrounding tissues is crucial to the establishment of neural circuits, but the underlying cellular and molecular mechanisms remain poorly understood. We show that neurons in a C. elegans sensory organ, called the amphid, undergo a collective dendrite extension to form the sensory nerve. The amphid neurons first assemble into a multicellular rosette. The vertex of the rosette, which becomes the dendrite tips, is attached to the anteriorly migrating epidermis and carried to the sensory depression, extruding the dendrites away from the neuronal cell bodies. Multiple adhesion molecules including DYF-7, SAX-7, HMR-1 and DLG-1 function redundantly in rosette-to-epidermis attachment. PAR-6 is localized to the rosette vertex and dendrite tips, and promotes DYF-7 localization and dendrite extension. Our results suggest a collective mechanism of neurite extension that is distinct from the classical pioneer-follower model and highlight the role of mechanical cues from surrounding tissues in shaping neurites. |
| 巻・号 | 8 |
| 公開日 | 2019-2-15 |
| DOI | 10.7554/eLife.38065 |
| PII | 38065 |
| PMID | 30767892 |
| PMC | PMC6400498 |
| MeSH | Animals Caenorhabditis elegans / embryology Caenorhabditis elegans / metabolism* Caenorhabditis elegans Proteins / metabolism Cell Adhesion Molecules / metabolism Cell Movement Dendrites / metabolism* Embryo, Nonmammalian / cytology Embryo, Nonmammalian / metabolism Epidermis / metabolism |
| IF | 7.551 |
| 引用数 | 3 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 5 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm1425 |