RRC ID 59394
著者 Okahata M, Wei AD, Ohta A, Kuhara A.
タイトル Cold acclimation via the KQT-2 potassium channel is modulated by oxygen in Caenorhabditis elegans.
ジャーナル Sci Adv
Abstract Adaptive responses to external temperatures are essential for survival in changing environments. We show here that environmental oxygen concentration affects cold acclimation in Caenorhabditis elegans and that this response is regulated by a KCNQ-type potassium channel, KQT-2. Depending on culture conditions, kqt-2 mutants showed supranormal cold acclimation, caused by abnormal thermosensation in ADL chemosensory neurons. ADL neurons are responsive to temperature via transient receptor potential channels-OSM-9, OCR-2, and OCR-1-with OCR-1 negatively regulating ADL function. Similarly, KQT-2 and KQT-3 regulate ADL activity, with KQT-2 positively regulating ADL function. Abnormal cold acclimation and acute temperature responses of ADL neurons in kqt-2 mutants were suppressed by an oxygen-receptor mutation in URX coelomic sensory neurons, which are electrically connected to ADL via RMG interneurons. Likewise, low oxygen suppressed supranormal kqt-2 cold acclimation. These data thus demonstrate a simple neuronal circuit integrating two different sensory modalities, temperature and oxygen, that determines cold acclimation.
巻・号 5(2)
ページ eaav3631
公開日 2019-2-1
DOI 10.1126/sciadv.aav3631
PII aav3631
PMID 30775442
PMC PMC6365114
MeSH Acclimatization* Animals Caenorhabditis elegans / physiology* Cold Temperature* Gene Expression KCNQ2 Potassium Channel / genetics KCNQ2 Potassium Channel / metabolism* Models, Biological Mutation Oxygen / metabolism* Sensory Receptor Cells / metabolism
IF 12.804
引用数 1
リソース情報
線虫 tm2418 tm2468 tm1770 tm830 tm1013 tm642 tm5415