RRC ID 59395
Author Park J, Choi W, Dar AR, Butcher RA, Kim K.
Title Neuropeptide Signaling Regulates Pheromone-Mediated Gene Expression of a Chemoreceptor Gene in C. elegans.
Journal Mol Cells
Abstract Animals need to be able to alter their developmental and behavioral programs in response to changing environmental conditions. This developmental and behavioral plasticity is mainly mediated by changes in gene expression. The knowledge of the mechanisms by which environmental signals are transduced and integrated to modulate changes in sensory gene expression is limited. Exposure to ascaroside pheromone has been reported to alter the expression of a subset of putative G protein-coupled chemosensory receptor genes in the ASI chemosensory neurons of C. elegans (Kim et al., 2009; Nolan et al., 2002; Peckol et al., 1999). Here we show that ascaroside pheromone reversibly represses expression of the str-3 chemoreceptor gene in the ASI neurons. Repression of str-3 expression can be initiated only at the L1 stage, but expression is restored upon removal of ascarosides at any developmental stage. Pheromone receptors including SRBC-64/66 and SRG-36/37 are required for str-3 repression. Moreover, pheromone-mediated str-3 repression is mediated by FLP-18 neuropeptide signaling via the NPR-1 neuropeptide receptor. These results suggest that environmental signals regulate chemosensory gene expression together with internal neuropeptide signals which, in turn, modulate behavior.
Volume 42(1)
Pages 28-35
Published 2019-1-31
DOI 10.14348/molcells.2018.0380
PII molcells.2018.0380
PMID 30453729
PMC PMC6354054
MeSH Animals Caenorhabditis elegans / drug effects Caenorhabditis elegans / genetics* Caenorhabditis elegans Proteins / genetics* Caenorhabditis elegans Proteins / metabolism Feeding Behavior / drug effects Gene Expression Regulation / drug effects* Genes, Helminth* Larva / drug effects Larva / genetics Mutation / genetics Neurons / drug effects Neurons / metabolism Neuropeptides / metabolism* Ovum / metabolism Pheromones / pharmacology* Receptors, Neuropeptide Y Receptors, Odorant / genetics* Receptors, Odorant / metabolism Signal Transduction* / drug effects Temperature
IF 3.533
Times Cited 1
C.elegans tm1946 tm2943 tm2179 tm1782