論文 - 詳細
| RRC ID | 59421 |
|---|---|
| 著者 | Wang W, Chaturbedi A, Wang M, An S, Santhi Velayudhan S, Lee SS. |
| タイトル | SET-9 and SET-26 are H3K4me3 readers and play critical roles in germline development and longevity. |
| ジャーナル | Elife |
| Abstract |
C. elegans SET-9 and SET-26 are highly homologous paralogs that share redundant functions in germline development, but SET-26 alone plays a key role in longevity and heat stress response. Whereas SET-26 is broadly expressed, SET-9 is only detectable in the germline, which likely accounts for their different biological roles. SET-9 and SET-26 bind to H3K4me3 with adjacent acetylation marks in vitro and in vivo. In the soma, SET-26 acts through DAF-16 to modulate longevity. In the germline, SET-9 and SET-26 restrict H3K4me3 domains around SET-9 and SET-26 binding sites, and regulate the expression of specific target genes, with critical consequence on germline development. SET-9 and SET-26 are highly conserved and our findings provide new insights into the functions of these H3K4me3 readers in germline development and longevity. |
| 巻・号 | 7 |
| 公開日 | 2018-5-1 |
| DOI | 10.7554/eLife.34970 |
| PII | 34970 |
| PMID | 29714684 |
| PMC | PMC6010342 |
| MeSH | Animals Caenorhabditis elegans / growth & development* Caenorhabditis elegans / physiology Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism* Gene Expression Profiling Gene Expression Regulation, Developmental* Germ Cells / cytology* Germ Cells / metabolism Heat-Shock Response Histones / genetics Histones / metabolism* Longevity* |
| IF | 7.551 |
| 引用数 | 6 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 9 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm2467 |