論文 - 詳細
| RRC ID | 59429 |
|---|---|
| 著者 | Zheng C, Jin FQ, Trippe BL, Wu J, Chalfie M. |
| タイトル | Inhibition of cell fate repressors secures the differentiation of the touch receptor neurons of Caenorhabditis elegans. |
| ジャーナル | Development |
| Abstract |
Terminal differentiation generates the specialized features and functions that allow postmitotic cells to acquire their distinguishing characteristics. This process is thought to be controlled by transcription factors called 'terminal selectors' that directly activate a set of downstream effector genes. In Caenorhabditis elegans, the differentiation of both the mechanosensory touch receptor neurons (TRNs) and the multidendritic nociceptor FLP neurons uses the terminal selectors UNC-86 and MEC-3. The FLP neurons fail to activate TRN genes, however, because a complex of two transcriptional repressors (EGL-44/EGL-46) prevents their expression. Here, we show that the ZEB family transcriptional factor ZAG-1 promotes TRN differentiation not by activating TRN genes but by preventing the expression of EGL-44/EGL-46. As EGL-44/EGL-46 also inhibits the production of ZAG-1, these proteins form a bistable, negative-feedback loop that regulates the choice between the two neuronal fates. |
| 巻・号 | 145(22) |
| 公開日 | 2018-11-15 |
| DOI | 10.1242/dev.168096 |
| PII | dev.168096 |
| PMID | 30291162 |
| PMC | PMC6262790 |
| MeSH | Animals Base Sequence Biomarkers / metabolism Caenorhabditis elegans / cytology* Caenorhabditis elegans / genetics Caenorhabditis elegans / metabolism* Caenorhabditis elegans Proteins / metabolism Cell Differentiation* Cell Lineage* Gene Expression Regulation, Developmental Models, Biological Mutation / genetics Neurons / cytology* Neurons / metabolism Penetrance RNA Interference Receptors, Cell Surface / metabolism* Time Factors Touch / physiology* Transcription Factors / metabolism |
| IF | 5.763 |
| 引用数 | 2 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 3 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm1359 tm2323 |