論文 - 詳細
| RRC ID | 59472 |
|---|---|
| 著者 | Coakley S, Ritchie FK, Galbraith KM, Hilliard MA. |
| タイトル | Epidermal control of axonal attachment via β-spectrin and the GTPase-activating protein TBC-10 prevents axonal degeneration. |
| ジャーナル | Nat Commun |
| Abstract |
Neurons are subjected to strain due to body movement and their location within organs and tissues. However, how they withstand these forces over the lifetime of an organism is still poorly understood. Here, focusing on touch receptor neuron-epidermis interactions using Caenorhabditis elegans as a model system, we show that UNC-70/β-spectrin and TBC-10, a conserved GTPase-activating protein, function non-cell-autonomously within the epidermis to dynamically maintain attachment of the axon. We reveal that, in response to strain, UNC-70/β-spectrin and TBC-10 stabilize trans-epidermal hemidesmosome attachment structures which otherwise become lost, causing axonal breakage and degeneration. Furthermore, we show that TBC-10 regulates axonal attachment and maintenance by inactivating RAB-35, and reveal functional conservation of these molecules with their vertebrate orthologs. Finally, we demonstrate that β-spectrin functions in this context non-cell-autonomously. We propose a model in which mechanically resistant epidermal attachment structures are maintained by UNC-70/β-spectrin and TBC-10 during movement, preventing axonal detachment and degeneration. |
| 巻・号 | 11(1) |
| ページ | 133 |
| 公開日 | 2020-1-9 |
| DOI | 10.1038/s41467-019-13795-x |
| PII | 10.1038/s41467-019-13795-x |
| PMID | 31919407 |
| PMC | PMC6952388 |
| MeSH | Animals Axons / physiology* Caenorhabditis elegans / physiology* Caenorhabditis elegans Proteins / metabolism* Cytoskeleton / physiology Epidermis / metabolism GTPase-Activating Proteins / metabolism* Hemidesmosomes / metabolism Spectrin / metabolism* Stress, Physiological / physiology* rab GTP-Binding Proteins / metabolism |
| IF | 11.878 |
| 引用数 | 0 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 34 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm2790 tm2907 |